{
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 "approach": "JOINT multi-experiment fit (single parameter set fits BOTH datasets) — identifiable & honest. Single-dataset fits reported only as descriptive upper bounds.",
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   },
   "provenance": [
    "LITERATURE-SYNTHESIZED CALIBRATION TARGET (not raw data); normalized 0..1 per axis.",
    "Muller-Rover et al. 2001 J Invest Dermatol - depilation-synchronized morphological staging anchoring telogen(d0)->anagen->catagen(~d17-21)->telogen(~d25-28) timeline.",
    "Greco et al. 2009 Cell Stem Cell - HFSC (Lgr5/CD34) activation at anagen onset followed by progeny differentiation; Wnt/BMP antagonism gating telogen->anagen competence.",
    "Lin et al. 2009 PLoS Genet - circadian clock control of hair cycle; coupling of cell-cycle/proliferation genes to anagen progression.",
    "Geyfman et al. 2012 PNAS - clock-gated proliferation and S-phase timing across anagen; Shh/Gli1 proliferative signaling early-mid anagen.",
    "Plikus et al. 2008 Nature - BMP2/BMP4 high in refractory telogen, suppressed for anagen competence, rising again at catagen; dermal BMP as inhibitory tone.",
    "Al-Nuaimi et al. 2012 J Invest Dermatol - quantitative hair-cycle clock/oscillator model framing of phase relationships and amplitudes."
   ],
   "notes": "Mouse dorsal hair-follicle gene/signal expression across one depilation-synchronized cycle (day0 depilation -> full anagen ~d8-12 -> anagen-catagen transition ~d17 -> catagen d21 -> telogen ~d28). Per-axis min-max normalized to 0..1; values are relative amplitudes, not absolute concentrations or fold-changes. Phase relationships encoded: Wnt(CTNNB1/LEF1/AXIN2) and BMP(BMP4/BMP2) are antiphase - Wnt rises as BMP falls into anagen, both reverse at catagen. SHH(SHH/GLI1) is a transient sharp pulse peaking early-mid anagen (d5-8), downstream of and lagging the initial Wnt rise, then fully off. DP(IGF1/VEGFA/FGF7) dermal-papilla support signals ramp with anagen and stay sustained through peak anagen before declining in catagen. HFSC(LGR5/CD34) shows transient bulge activation at anagen onset (peak ~d3) then returns toward baseline as activated stem cells produce differentiating progeny (signal dilution/exit from niche). FGF5 is a sharp late spike (peak ~d17) acting as the anagen->catagen terminator, the last axis to fire. hair_index is the observable anagen/shaft phenotype lagging the molecular signals: ~0 in telogen, ramps during anagen, plateaus at peak anagen (d12-17), regresses through catagen back to ~0. Recommended use: phase-aligned shape/amplitude calibration target for ODE axes, NOT for absolute-scale fitting."
  },
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   },
   "provenance": [
    "GSE11186 (GEO) — C57BL/6 dorsal skin, depilation-synchronized hair cycle (D3–D17)"
   ],
   "notes": ""
  }
 },
 "summary": {
  "method": "joint multi-experiment (COPASI LM)",
  "joint_r2": {
   "reference": 0.745,
   "gse11186": 0.418
  },
  "loocv_cv_r2": 0.43,
  "robust_axes": [
   "F",
   "A"
  ],
  "n_params": 28,
  "aicc": -257.06,
  "honesty_note": "joint R² < 단일적합 R² 이지만 식별가능·예측적. FGF5/Hair 축이 이상화+실측 데이터 양쪽에서 견고. Wnt/BMP/SHH/HFSC 는 전체피부 실측 노이즈로 약함."
 }
}