{ "_description": "기전→단백질 네트워크→시간(개월) 변화. 노드=단백질, 엣지=활성/억제, 노드 활성=질환평형+회복·r(t)·(건강−질환). 치료별 표적 그룹이 달라 다른 단백질을 변화시킴.", "nodes": [ { "id": "AR", "label": "AR", "group": "androgen", "x": 7, "y": 22 }, { "id": "SRD5A2", "label": "SRD5A2", "group": "androgen", "x": 7, "y": 36 }, { "id": "IFNG", "label": "IFNG", "group": "immune", "x": 7, "y": 62 }, { "id": "CD8A", "label": "CD8A", "group": "immune", "x": 7, "y": 76 }, { "id": "HLA-DQB1", "label": "HLA-DQB1", "group": "immune", "x": 7, "y": 90 }, { "id": "CXCL10", "label": "CXCL10", "group": "immune", "x": 22, "y": 84 }, { "id": "DKK1", "label": "DKK1", "group": "wnt_antag", "x": 27, "y": 26 }, { "id": "SFRP1", "label": "SFRP1", "group": "wnt_antag", "x": 27, "y": 40 }, { "id": "BMP4", "label": "BMP4", "group": "bmp", "x": 30, "y": 54 }, { "id": "ID1", "label": "ID1", "group": "bmp", "x": 42, "y": 60 }, { "id": "WNT10B", "label": "WNT10B", "group": "wnt", "x": 46, "y": 12 }, { "id": "CTNNB1", "label": "β-catenin", "group": "wnt", "x": 48, "y": 24 }, { "id": "LEF1", "label": "LEF1", "group": "wnt", "x": 60, "y": 30 }, { "id": "AXIN2", "label": "AXIN2", "group": "wnt", "x": 60, "y": 16 }, { "id": "SHH", "label": "SHH", "group": "shh", "x": 50, "y": 70 }, { "id": "GLI1", "label": "GLI1", "group": "shh", "x": 62, "y": 66 }, { "id": "SOX2", "label": "SOX2", "group": "dp", "x": 70, "y": 24 }, { "id": "VCAN", "label": "VCAN", "group": "dp", "x": 72, "y": 38 }, { "id": "ALPL", "label": "ALPL", "group": "dp", "x": 70, "y": 50 }, { "id": "KRT15", "label": "KRT15", "group": "hfsc", "x": 72, "y": 64 }, { "id": "CD34", "label": "CD34", "group": "hfsc", "x": 72, "y": 78 }, { "id": "LGR5", "label": "LGR5", "group": "hfsc", "x": 72, "y": 90 }, { "id": "KRT85", "label": "KRT85", "group": "hair", "x": 92, "y": 34 }, { "id": "KRT35", "label": "KRT35", "group": "hair", "x": 92, "y": 50 } ], "edges": [ { "from": "AR", "to": "DKK1", "type": "activate" }, { "from": "SRD5A2", "to": "AR", "type": "activate" }, { "from": "AR", "to": "SFRP1", "type": "activate" }, { "from": "DKK1", "to": "CTNNB1", "type": "inhibit" }, { "from": "SFRP1", "to": "WNT10B", "type": "inhibit" }, { "from": "WNT10B", "to": "CTNNB1", "type": "activate" }, { "from": "CTNNB1", "to": "LEF1", "type": "activate" }, { "from": "CTNNB1", "to": "AXIN2", "type": "activate" }, { "from": "LEF1", "to": "KRT85", "type": "activate" }, { "from": "LEF1", "to": "KRT35", "type": "activate" }, { "from": "BMP4", "to": "ID1", "type": "activate" }, { "from": "ID1", "to": "CTNNB1", "type": "inhibit" }, { "from": "BMP4", "to": "KRT35", "type": "inhibit" }, { "from": "CTNNB1", "to": "SHH", "type": "activate" }, { "from": "SHH", "to": "GLI1", "type": "activate" }, { "from": "GLI1", "to": "SOX2", "type": "activate" }, { "from": "CTNNB1", "to": "SOX2", "type": "activate" }, { "from": "SOX2", "to": "VCAN", "type": "activate" }, { "from": "VCAN", "to": "ALPL", "type": "activate" }, { "from": "ALPL", "to": "KRT35", "type": "activate" }, { "from": "SOX2", "to": "LEF1", "type": "activate" }, { "from": "CTNNB1", "to": "KRT15", "type": "activate" }, { "from": "KRT15", "to": "CD34", "type": "activate" }, { "from": "CD34", "to": "LGR5", "type": "activate" }, { "from": "LGR5", "to": "KRT35", "type": "activate" }, { "from": "IFNG", "to": "CXCL10", "type": "activate" }, { "from": "HLA-DQB1", "to": "CD8A", "type": "activate" }, { "from": "CD8A", "to": "IFNG", "type": "activate" }, { "from": "CXCL10", "to": "CD8A", "type": "activate" }, { "from": "CD8A", "to": "KRT35", "type": "inhibit" }, { "from": "IFNG", "to": "LGR5", "type": "inhibit" } ], "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "scenarios": { "AGA|untreated": { "label": "남성형 탈모 · 무치료", "drug": "untreated", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15 ] }, "targets": [] }, "AGA|finasteride": { "label": "남성형 탈모 · 피나스테리드", "drug": "finasteride", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.766, 0.694, 0.582, 0.471, 0.404, 0.338, 0.314, 0.302 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.766, 0.694, 0.582, 0.471, 0.404, 0.338, 0.314, 0.302 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.793, 0.702, 0.559, 0.418, 0.332, 0.249, 0.218, 0.202 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.793, 0.702, 0.559, 0.418, 0.332, 0.249, 0.218, 0.202 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.724, 0.676, 0.601, 0.527, 0.482, 0.438, 0.421, 0.413 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.724, 0.676, 0.601, 0.527, 0.482, 0.438, 0.421, 0.413 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.314, 0.393, 0.518, 0.641, 0.716, 0.789, 0.816, 0.83 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.314, 0.393, 0.518, 0.641, 0.716, 0.789, 0.816, 0.83 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.314, 0.393, 0.518, 0.641, 0.716, 0.789, 0.816, 0.83 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.314, 0.393, 0.518, 0.641, 0.716, 0.789, 0.816, 0.83 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.354, 0.399, 0.47, 0.541, 0.584, 0.626, 0.641, 0.649 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.354, 0.399, 0.47, 0.541, 0.584, 0.626, 0.641, 0.649 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.404, 0.449, 0.52, 0.591, 0.634, 0.676, 0.691, 0.699 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.404, 0.449, 0.52, 0.591, 0.634, 0.676, 0.691, 0.699 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.404, 0.449, 0.52, 0.591, 0.634, 0.676, 0.691, 0.699 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.445, 0.483, 0.543, 0.602, 0.638, 0.674, 0.686, 0.693 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.445, 0.483, 0.543, 0.602, 0.638, 0.674, 0.686, 0.693 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.445, 0.483, 0.543, 0.602, 0.638, 0.674, 0.686, 0.693 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.261, 0.354, 0.5, 0.646, 0.734, 0.82, 0.852, 0.868 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.261, 0.354, 0.5, 0.646, 0.734, 0.82, 0.852, 0.868 ] }, "targets": [ "androgen", "hair", "wnt", "wnt_antag" ] }, "AGA|dutasteride": { "label": "남성형 탈모 · 두타스테리드", "drug": "dutasteride", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.75, 0.669, 0.547, 0.436, 0.374, 0.322, 0.307, 0.301 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.75, 0.669, 0.547, 0.436, 0.374, 0.322, 0.307, 0.301 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.773, 0.669, 0.515, 0.373, 0.295, 0.229, 0.209, 0.201 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.773, 0.669, 0.515, 0.373, 0.295, 0.229, 0.209, 0.201 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.709, 0.651, 0.565, 0.485, 0.442, 0.405, 0.394, 0.389 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.709, 0.651, 0.565, 0.485, 0.442, 0.405, 0.394, 0.389 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.337, 0.433, 0.576, 0.707, 0.779, 0.84, 0.858, 0.865 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.337, 0.433, 0.576, 0.707, 0.779, 0.84, 0.858, 0.865 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.337, 0.433, 0.576, 0.707, 0.779, 0.84, 0.858, 0.865 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.337, 0.433, 0.576, 0.707, 0.779, 0.84, 0.858, 0.865 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.368, 0.424, 0.507, 0.583, 0.624, 0.66, 0.67, 0.675 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.368, 0.424, 0.507, 0.583, 0.624, 0.66, 0.67, 0.675 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.421, 0.479, 0.565, 0.644, 0.687, 0.724, 0.735, 0.74 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.421, 0.479, 0.565, 0.644, 0.687, 0.724, 0.735, 0.74 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.421, 0.479, 0.565, 0.644, 0.687, 0.724, 0.735, 0.74 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.457, 0.504, 0.573, 0.637, 0.672, 0.702, 0.711, 0.715 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.457, 0.504, 0.573, 0.637, 0.672, 0.702, 0.711, 0.715 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.457, 0.504, 0.573, 0.637, 0.672, 0.702, 0.711, 0.715 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.288, 0.401, 0.569, 0.723, 0.807, 0.879, 0.901, 0.909 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.288, 0.401, 0.569, 0.723, 0.807, 0.879, 0.901, 0.909 ] }, "targets": [ "androgen", "hair", "wnt", "wnt_antag" ] }, "AGA|minoxidil": { "label": "남성형 탈모 · 미녹시딜", "drug": "minoxidil", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.884, 0.856, 0.835, 0.805, 0.781, 0.77, 0.762, 0.761, 0.76 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.884, 0.856, 0.835, 0.805, 0.781, 0.77, 0.762, 0.761, 0.76 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.764, 0.737, 0.716, 0.687, 0.663, 0.652, 0.644, 0.642, 0.642 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.764, 0.737, 0.716, 0.687, 0.663, 0.652, 0.644, 0.642, 0.642 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.26, 0.326, 0.378, 0.45, 0.508, 0.535, 0.555, 0.559, 0.56 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.26, 0.326, 0.378, 0.45, 0.508, 0.535, 0.555, 0.559, 0.56 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.26, 0.326, 0.378, 0.45, 0.508, 0.535, 0.555, 0.559, 0.56 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.26, 0.326, 0.378, 0.45, 0.508, 0.535, 0.555, 0.559, 0.56 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.341, 0.409, 0.463, 0.536, 0.596, 0.625, 0.644, 0.649, 0.65 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.341, 0.409, 0.463, 0.536, 0.596, 0.625, 0.644, 0.649, 0.65 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.409, 0.506, 0.582, 0.688, 0.773, 0.814, 0.842, 0.848, 0.85 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.409, 0.506, 0.582, 0.688, 0.773, 0.814, 0.842, 0.848, 0.85 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.409, 0.506, 0.582, 0.688, 0.773, 0.814, 0.842, 0.848, 0.85 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.442, 0.512, 0.566, 0.641, 0.702, 0.731, 0.751, 0.756, 0.757 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.442, 0.512, 0.566, 0.641, 0.702, 0.731, 0.751, 0.756, 0.757 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.442, 0.512, 0.566, 0.641, 0.702, 0.731, 0.751, 0.756, 0.757 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.225, 0.35, 0.447, 0.582, 0.692, 0.744, 0.78, 0.788, 0.79 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.225, 0.35, 0.447, 0.582, 0.692, 0.744, 0.78, 0.788, 0.79 ] }, "targets": [ "dp" ] }, "AGA|combo": { "label": "남성형 탈모 · 피나+미녹 병용", "drug": "combo", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.792, 0.694, 0.616, 0.502, 0.404, 0.353, 0.314, 0.304, 0.3 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.792, 0.694, 0.616, 0.502, 0.404, 0.353, 0.314, 0.304, 0.3 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.826, 0.702, 0.602, 0.458, 0.332, 0.268, 0.218, 0.205, 0.2 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.826, 0.702, 0.602, 0.458, 0.332, 0.268, 0.218, 0.205, 0.2 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.741, 0.676, 0.623, 0.547, 0.482, 0.448, 0.421, 0.414, 0.412 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.741, 0.676, 0.623, 0.547, 0.482, 0.448, 0.421, 0.414, 0.412 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.284, 0.393, 0.481, 0.607, 0.716, 0.773, 0.816, 0.828, 0.832 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.284, 0.393, 0.481, 0.607, 0.716, 0.773, 0.816, 0.828, 0.832 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.284, 0.393, 0.481, 0.607, 0.716, 0.773, 0.816, 0.828, 0.832 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.284, 0.393, 0.481, 0.607, 0.716, 0.773, 0.816, 0.828, 0.832 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.337, 0.399, 0.449, 0.521, 0.584, 0.616, 0.641, 0.648, 0.65 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.337, 0.399, 0.449, 0.521, 0.584, 0.616, 0.641, 0.648, 0.65 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.403, 0.492, 0.563, 0.666, 0.756, 0.802, 0.837, 0.847, 0.85 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.403, 0.492, 0.563, 0.666, 0.756, 0.802, 0.837, 0.847, 0.85 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.403, 0.492, 0.563, 0.666, 0.756, 0.802, 0.837, 0.847, 0.85 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.438, 0.501, 0.552, 0.626, 0.69, 0.722, 0.748, 0.755, 0.757 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.438, 0.501, 0.552, 0.626, 0.69, 0.722, 0.748, 0.755, 0.757 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.438, 0.501, 0.552, 0.626, 0.69, 0.722, 0.748, 0.755, 0.757 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.226, 0.354, 0.457, 0.605, 0.734, 0.8, 0.852, 0.865, 0.87 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.226, 0.354, 0.457, 0.605, 0.734, 0.8, 0.852, 0.865, 0.87 ] }, "targets": [ "androgen", "dp", "hair", "wnt", "wnt_antag" ] }, "AA|untreated": { "label": "원형 탈모 · 무치료", "drug": "untreated", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22, 0.22 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35, 0.35 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4, 0.4 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15, 0.15 ] }, "targets": [] }, "AA|JAK_inhibitor": { "label": "원형 탈모 · JAK 억제제", "drug": "JAK_inhibitor", "months": [ 0, 0.25, 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 18, 24, 36 ], "activity": { "AR": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "SRD5A2": [ 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85, 0.85 ], "IFNG": [ 0.9, 0.9, 0.9, 0.9, 0.812, 0.734, 0.605, 0.504, 0.365, 0.252, 0.198, 0.161, 0.152, 0.15 ], "CD8A": [ 0.9, 0.9, 0.9, 0.9, 0.812, 0.734, 0.605, 0.504, 0.365, 0.252, 0.198, 0.161, 0.152, 0.15 ], "HLA-DQB1": [ 0.9, 0.9, 0.9, 0.9, 0.812, 0.734, 0.605, 0.504, 0.365, 0.252, 0.198, 0.161, 0.152, 0.15 ], "CXCL10": [ 0.9, 0.9, 0.9, 0.9, 0.812, 0.734, 0.605, 0.504, 0.365, 0.252, 0.198, 0.161, 0.152, 0.15 ], "DKK1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "SFRP1": [ 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9, 0.9 ], "BMP4": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "ID1": [ 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78, 0.78 ], "WNT10B": [ 0.22, 0.22, 0.22, 0.22, 0.244, 0.265, 0.3, 0.328, 0.366, 0.396, 0.411, 0.421, 0.423, 0.424 ], "CTNNB1": [ 0.22, 0.22, 0.22, 0.22, 0.244, 0.265, 0.3, 0.328, 0.366, 0.396, 0.411, 0.421, 0.423, 0.424 ], "LEF1": [ 0.22, 0.22, 0.22, 0.22, 0.244, 0.265, 0.3, 0.328, 0.366, 0.396, 0.411, 0.421, 0.423, 0.424 ], "AXIN2": [ 0.22, 0.22, 0.22, 0.22, 0.244, 0.265, 0.3, 0.328, 0.366, 0.396, 0.411, 0.421, 0.423, 0.424 ], "SHH": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "GLI1": [ 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3, 0.3 ], "SOX2": [ 0.35, 0.35, 0.35, 0.35, 0.374, 0.394, 0.429, 0.456, 0.493, 0.523, 0.537, 0.547, 0.549, 0.55 ], "VCAN": [ 0.35, 0.35, 0.35, 0.35, 0.374, 0.394, 0.429, 0.456, 0.493, 0.523, 0.537, 0.547, 0.549, 0.55 ], "ALPL": [ 0.35, 0.35, 0.35, 0.35, 0.374, 0.394, 0.429, 0.456, 0.493, 0.523, 0.537, 0.547, 0.549, 0.55 ], "KRT15": [ 0.4, 0.4, 0.4, 0.4, 0.435, 0.465, 0.516, 0.555, 0.61, 0.654, 0.675, 0.69, 0.693, 0.694 ], "CD34": [ 0.4, 0.4, 0.4, 0.4, 0.435, 0.465, 0.516, 0.555, 0.61, 0.654, 0.675, 0.69, 0.693, 0.694 ], "LGR5": [ 0.4, 0.4, 0.4, 0.4, 0.435, 0.465, 0.516, 0.555, 0.61, 0.654, 0.675, 0.69, 0.693, 0.694 ], "KRT85": [ 0.15, 0.15, 0.15, 0.15, 0.235, 0.309, 0.433, 0.53, 0.664, 0.773, 0.824, 0.86, 0.868, 0.87 ], "KRT35": [ 0.15, 0.15, 0.15, 0.15, 0.235, 0.309, 0.433, 0.53, 0.664, 0.773, 0.824, 0.86, 0.868, 0.87 ] }, "targets": [ "hair", "immune" ] } }, "groups": { "androgen": "안드로겐 드라이버", "wnt_antag": "Wnt 길항", "wnt": "Wnt(친모발)", "bmp": "BMP(항모발)", "shh": "SHH", "dp": "진피유두", "hfsc": "모낭줄기세포", "hair": "모발 산출", "immune": "면역(AA)" } }