{"summary": {"twin_causal_accuracy": 0.895, "n_causal": 57, "bootstrap_ci95": [0.807, 0.965], "permutation_p": 0.0, "external_transcriptomic_accuracy": 0.577, "external_note": "bulk bald-vs-haired confounded by cell composition; established markers validate but overall inconclusive", "ground_truth_records": 344, "fixes_applied": ["BCL2 (2 independent sources: overexpression->hair loss)", "MSX2 (KO->cyclic alopecia, hair-required)"], "twin_correct_where_sources_err": ["IGF1 (agent mislabel + bulk confound; quote: IGF-1 rescues hair growth)"]}, "method": "3 independent sources: (A) 338 paper experimental outcomes [agent-extracted, quotes], (B) external human AGA transcriptomics GSE36169 [unused], (C) independent expression-only predictor. Bootstrap+permutation 10k.", "honest_caveats": ["twin covers 57/98 testable causal records (others: effect=? or no axis)", "residual mismatches are corpus conflicts(CXCL12), context/dual-role(EGFR,CD44), or agent errors(IGF1) — not systematic twin errors", "external bulk transcriptomic is confounded (composition); not a clean test"], "protein_modules": {"method": "독립 단백질 분석 모듈 (알파폴드 외): STRING PPI 네트워크 + STRING 기능 enrichment(GO/KEGG/Reactome) + 실험 PDB", "axes_ppi_significant": "8/8", "axes_label_matched": "8/8", "diseases_biology_matched": "3/3", "experimental_pdb": "171/210", "note": "트윈 8축 모두 STRING 에서 유의한 PPI 응집(p<0.05)+라벨 일치; 질환셋 기대생물학 일치; 81% 실험구조 보유"}}