{
  "_description": "개인화+데이터 동화: 초기 반응 동화 → 후기 forecast 개선 검정(시험암=유사개인), 동화 구간수축 시연, 합성환자 정확성. 개인환자 IPD 확보 후 환자단위 재검정 필요.",
  "honest_caveat": "시험암 평균은 저잡음 → 개선이 개인환자보다 과대평가될 수 있음. ODE-수준 개인화는 omics 필요.",
  "forecast_skill": {
    "by_trajectory": [
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        "id": "deuruxolitinib_THRIVE-AA1_12mg",
        "class": "JAK_inhibitor",
        "n_obs": 3,
        "n_future": 3,
        "rmse_pop": 2.219,
        "rmse_personal": 1.453,
        "improve_pct": 34.5,
        "cover_personal": 1.0,
        "cover_pop": 1.0
      },
      {
        "id": "deuruxolitinib_THRIVE-AA1_8mg",
        "class": "JAK_inhibitor",
        "n_obs": 3,
        "n_future": 3,
        "rmse_pop": 5.651,
        "rmse_personal": 3.071,
        "improve_pct": 45.7,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "deuruxolitinib_THRIVE-AA2_12mg",
        "class": "JAK_inhibitor",
        "n_obs": 3,
        "n_future": 3,
        "rmse_pop": 4.582,
        "rmse_personal": 1.802,
        "improve_pct": 60.7,
        "cover_personal": 1.0,
        "cover_pop": 0.33
      },
      {
        "id": "brepocitinib_NCT02974868",
        "class": "JAK_inhibitor",
        "n_obs": 4,
        "n_future": 3,
        "rmse_pop": 16.199,
        "rmse_personal": 5.027,
        "improve_pct": 69.0,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "ritlecitinib_NCT02974868",
        "class": "JAK_inhibitor",
        "n_obs": 4,
        "n_future": 3,
        "rmse_pop": 11.686,
        "rmse_personal": 4.949,
        "improve_pct": 57.6,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "dutasteride_0.5mg_NCT01231607",
        "class": "dutasteride",
        "n_obs": 2,
        "n_future": 1,
        "rmse_pop": 45.955,
        "rmse_personal": 46.306,
        "improve_pct": -0.8,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "dutasteride_0.5mg_NCT00441116",
        "class": "dutasteride",
        "n_obs": 2,
        "n_future": 1,
        "rmse_pop": 0.369,
        "rmse_personal": 0.025,
        "improve_pct": 93.2,
        "cover_personal": 1.0,
        "cover_pop": 1.0
      },
      {
        "id": "finasteride_1mg_NCT01231607",
        "class": "finasteride",
        "n_obs": 2,
        "n_future": 1,
        "rmse_pop": 30.766,
        "rmse_personal": 27.729,
        "improve_pct": 9.9,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "finasteride_1mg_Kaufman_2yr",
        "class": "finasteride",
        "n_obs": 2,
        "n_future": 1,
        "rmse_pop": 28.258,
        "rmse_personal": 21.748,
        "improve_pct": 23.0,
        "cover_personal": 1.0,
        "cover_pop": 0.0
      },
      {
        "id": "finasteride_oral_P3074_NCT03004469",
        "class": "finasteride",
        "n_obs": 2,
        "n_future": 1,
        "rmse_pop": 17.453,
        "rmse_personal": 16.178,
        "improve_pct": 7.3,
        "cover_personal": 0.0,
        "cover_pop": 0.0
      }
    ],
    "overall": {
      "n": 10,
      "mean_improve_pct": 40.0,
      "cover_personal": 0.9,
      "cover_pop": 0.23,
      "personal_wins": 9
    }
  },
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}