1 line
136 KiB
JSON
1 line
136 KiB
JSON
{"summary": {"n_nodes": 476, "n_edges": 817, "by_type": {"protein": 210, "pathway": 80, "disease": 7, "axis": 8, "drug": 171}}, "nodes": [{"id": "P:CTNNB1", "label": "CTNNB1", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 10, "in_model": true, "diseases": ["AA", "AGA", "CIA"], "pathway": "Wnt/β-catenin", "plddt": 81.1, "degree": 9}, {"id": "PW:Wnt/β-catenin", "label": "Wnt/β-catenin", "type": "pathway", "degree": 8}, {"id": "D:AA", "label": "AA", "type": "disease", "degree": 74}, {"id": "D:AGA", "label": "AGA", "type": "disease", "degree": 108}, {"id": "D:CIA", "label": "CIA", "type": "disease", "degree": 66}, {"id": "AX:Wnt", "label": "Wnt/β-catenin", "type": "axis", "axis": "Wnt", "degree": 15}, {"id": "R:Wnt agonist", "label": "Wnt agonist", "type": "drug", "degree": 1}, {"id": "R:Wnt/beta-catenin agonists (investigational)", "label": "Wnt/beta-catenin agonists (investigational)", "type": "drug", "degree": 1}, {"id": "R:valproate", "label": "valproate", "type": "drug", "degree": 1}, {"id": "R:valproic acid (GSK3 inhibition, off-label)", "label": "valproic acid (GSK3 inhibition, off-label)", "type": "drug", "degree": 1}, {"id": "P:AR", "label": "AR", "type": "protein", "role": "driver", "twin_node": "AND", "n_evidence": 12, "in_model": true, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 57.3, "degree": 9}, {"id": "PW:Androgen signaling", "label": "Androgen signaling", "type": "pathway", "degree": 6}, {"id": "AX:AND", "label": "안드로겐 축 (AR/DHT)", "type": "axis", "axis": "AND", "degree": 6}, {"id": "R:GT20029 (Kintor, topical AR-PROTAC, Phase 2)", "label": "GT20029 (Kintor, topical AR-PROTAC, Phase 2)", "type": "drug", "degree": 1}, {"id": "R:RU58841", "label": "RU58841", "type": "drug", "degree": 1}, {"id": "R:RU58841 (clascoterone-class topical antiandrogens)", "label": "RU58841 (clascoterone-class topical antiandrogens)", "type": "drug", "degree": 1}, {"id": "R:bicalutamide", "label": "bicalutamide", "type": "drug", "degree": 1}, {"id": "R:clascoterone", "label": "clascoterone", "type": "drug", "degree": 1}, {"id": "R:dutasteride (indirect)", "label": "dutasteride (indirect)", "type": "drug", "degree": 1}, {"id": "P:SRD5A2", "label": "SRD5A2", "type": "protein", "role": "driver", "twin_node": "AND", "n_evidence": 9, "in_model": true, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 94.4, "degree": 5}, {"id": "R:dutasteride", "label": "dutasteride", "type": "drug", "degree": 2}, {"id": "R:finasteride", "label": "finasteride", "type": "drug", "degree": 1}, {"id": "P:VEGFA", "label": "VEGFA", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 4, "in_model": true, "diseases": ["AA", "AGA", "CIA"], "pathway": "Growth factor", "plddt": 63.9, "degree": 9}, {"id": "PW:Growth factor", "label": "Growth factor", "type": "pathway", "degree": 14}, {"id": "AX:DP", "label": "진피유두/성장인자", "type": "axis", "axis": "DP", "degree": 23}, {"id": "R:VEGF microneedle", "label": "VEGF microneedle", "type": "drug", "degree": 1}, {"id": "R:minoxidil (upregulates VEGFA)", "label": "minoxidil (upregulates VEGFA)", "type": "drug", "degree": 1}, {"id": "R:minoxidil(indirect)", "label": "minoxidil(indirect)", "type": "drug", "degree": 1}, {"id": "R:platelet-rich plasma (delivers VEGFA)", "label": "platelet-rich plasma (delivers VEGFA)", "type": "drug", "degree": 1}, {"id": "P:BCL2", "label": "BCL2", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 3, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 72.0, "degree": 5}, {"id": "PW:Cell-cycle/apoptosis", "label": "Cell-cycle/apoptosis", "type": "pathway", "degree": 12}, {"id": "AX:APO", "label": "세포사멸/산화", "type": "axis", "axis": "APO", "degree": 35}, {"id": "R:Venetoclax (BCL2 inhibitor; opposing context)", "label": "Venetoclax (BCL2 inhibitor; opposing context)", "type": "drug", "degree": 1}, {"id": "P:IFNG", "label": "IFNG", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 4, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 85.3, "degree": 5}, {"id": "PW:JAK-STAT", "label": "JAK-STAT", "type": "pathway", "degree": 16}, {"id": "AX:INF", "label": "염증/JAK-STAT", "type": "axis", "axis": "INF", "degree": 52}, {"id": "R:IFN-gamma pathway blocked indirectly by JAK inhibitors", "label": "IFN-gamma pathway blocked indirectly by JAK inhibitors", "type": "drug", "degree": 1}, {"id": "R:anti-IFNγ", "label": "anti-IFNγ", "type": "drug", "degree": 1}, {"id": "P:STAT3", "label": "STAT3", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 3, "in_model": true, "diseases": ["AA", "AGA"], "pathway": "JAK-STAT", "plddt": 84.9, "degree": 4}, {"id": "P:TP53", "label": "TP53", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 3, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 75.1, "degree": 9}, {"id": "R:ALRN-6924 (stapled peptide, clinical)", "label": "ALRN-6924 (stapled peptide, clinical)", "type": "drug", "degree": 1}, {"id": "R:Cyclophosphamide (inducer, not therapeutic)", "label": "Cyclophosphamide (inducer, not therapeutic)", "type": "drug", "degree": 1}, {"id": "R:Pifithrin-alpha (experimental)", "label": "Pifithrin-alpha (experimental)", "type": "drug", "degree": 1}, {"id": "R:Pifithrin-alpha (p53 inhibitor, experimental)", "label": "Pifithrin-alpha (p53 inhibitor, experimental)", "type": "drug", "degree": 1}, {"id": "R:p53 inhibitor(temporary)", "label": "p53 inhibitor(temporary)", "type": "drug", "degree": 1}, {"id": "P:AKT1", "label": "AKT1", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 2, "in_model": true, "diseases": ["AA", "AGA", "CIA"], "pathway": "PI3K-AKT-mTOR", "plddt": 83.0, "degree": 6}, {"id": "PW:PI3K-AKT-mTOR", "label": "PI3K-AKT-mTOR", "type": "pathway", "degree": 4}, {"id": "R:minoxidil (activates AKT)", "label": "minoxidil (activates AKT)", "type": "drug", "degree": 1}, {"id": "P:CD34", "label": "CD34", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 2, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "HFSC niche", "plddt": 60.4, "degree": 4}, {"id": "PW:HFSC niche", "label": "HFSC niche", "type": "pathway", "degree": 5}, {"id": "AX:HFSC", "label": "모낭 줄기세포", "type": "axis", "axis": "HFSC", "degree": 16}, {"id": "P:DKK1", "label": "DKK1", "type": "protein", "role": "driver", "twin_node": "Wnt", "n_evidence": 2, "in_model": true, "diseases": ["AA", "AGA"], "pathway": "Wnt/β-catenin", "plddt": 70.0, "degree": 7}, {"id": "R:anti-DKK1", "label": "anti-DKK1", "type": "drug", "degree": 1}, {"id": "R:anti-DKK1 / DKK1 inhibitors (investigational)", "label": "anti-DKK1 / DKK1 inhibitors (investigational)", "type": "drug", "degree": 1}, {"id": "R:anti-DKK1 antibodies (preclinical)", "label": "anti-DKK1 antibodies (preclinical)", "type": "drug", "degree": 1}, {"id": "P:FOXP3", "label": "FOXP3", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 2, "in_model": true, "diseases": ["AA"], "pathway": "Immune tolerance", "plddt": 56.7, "degree": 5}, {"id": "PW:Immune tolerance", "label": "Immune tolerance", "type": "pathway", "degree": 2}, {"id": "R:IL-2/Treg", "label": "IL-2/Treg", "type": "drug", "degree": 1}, {"id": "R:low-dose IL-2 (Treg-restoring, investigational)", "label": "low-dose IL-2 (Treg-restoring, investigational)", "type": "drug", "degree": 1}, {"id": "P:IL15", "label": "IL15", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 2, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 84.7, "degree": 6}, {"id": "R:anti-IL-15 / anti-IL-15Rbeta (investigational)", "label": "anti-IL-15 / anti-IL-15Rbeta (investigational)", "type": "drug", "degree": 1}, {"id": "R:anti-IL-15Rbeta antibodies (preclinical/early clinical)", "label": "anti-IL-15Rbeta antibodies (preclinical/early clinical)", "type": "drug", "degree": 1}, {"id": "R:anti-IL15", "label": "anti-IL15", "type": "drug", "degree": 1}, {"id": "P:JAK1", "label": "JAK1", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 9, "in_model": true, "diseases": ["AA", "CIA"], "pathway": "JAK-STAT", "plddt": 85.6, "degree": 10}, {"id": "R:INCB054707", "label": "INCB054707", "type": "drug", "degree": 1}, {"id": "R:abrocitinib", "label": "abrocitinib", "type": "drug", "degree": 1}, {"id": "R:baricitinib", "label": "baricitinib", "type": "drug", "degree": 2}, {"id": "R:ruxolitinib", "label": "ruxolitinib", "type": "drug", "degree": 2}, {"id": "R:tofacitinib", "label": "tofacitinib", "type": "drug", "degree": 3}, {"id": "R:upadacitinib", "label": "upadacitinib", "type": "drug", "degree": 1}, {"id": "P:JAK2", "label": "JAK2", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 5, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 86.9, "degree": 6}, {"id": "P:JAK3", "label": "JAK3", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 5, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 85.7, "degree": 5}, {"id": "R:ritlecitinib", "label": "ritlecitinib", "type": "drug", "degree": 1}, {"id": "P:SHH", "label": "SHH", "type": "protein", "role": "protector", "twin_node": "SHH", "n_evidence": 2, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Hedgehog", "plddt": 78.4, "degree": 7}, {"id": "PW:Hedgehog", "label": "Hedgehog", "type": "pathway", "degree": 3}, {"id": "AX:SHH", "label": "Hedgehog", "type": "axis", "axis": "SHH", "degree": 3}, {"id": "R:SAG / hedgehog agonists (experimental)", "label": "SAG / hedgehog agonists (experimental)", "type": "drug", "degree": 1}, {"id": "R:SAG agonist", "label": "SAG agonist", "type": "drug", "degree": 1}, {"id": "R:Vismodegib (antagonist; opposing context)", "label": "Vismodegib (antagonist; opposing context)", "type": "drug", "degree": 1}, {"id": "P:STAT1", "label": "STAT1", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 2, "in_model": true, "diseases": ["AA", "CIA"], "pathway": "JAK-STAT", "plddt": 87.2, "degree": 4}, {"id": "P:CYP19A1", "label": "CYP19A1", "type": "protein", "role": "protector", "twin_node": "AND", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 91.4, "degree": 4}, {"id": "R:aromatase inhibitors (anastrozole; promote hair loss by blocking this protective route)", "label": "aromatase inhibitors (anastrozole; promote hair loss by blocking this protective route)", "type": "drug", "degree": 1}, {"id": "P:EGFR", "label": "EGFR", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA", "Scarring"], "pathway": "Growth factor", "plddt": 75.9, "degree": 9}, {"id": "D:Scarring", "label": "Scarring", "type": "disease", "degree": 3}, {"id": "R:Cetuximab", "label": "Cetuximab", "type": "drug", "degree": 1}, {"id": "R:EGFR inhibitor(유발)", "label": "EGFR inhibitor(유발)", "type": "drug", "degree": 1}, {"id": "R:Erlotinib", "label": "Erlotinib", "type": "drug", "degree": 1}, {"id": "R:Gefitinib (inhibitors that perturb hair)", "label": "Gefitinib (inhibitors that perturb hair)", "type": "drug", "degree": 1}, {"id": "P:GPX4", "label": "GPX4", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Oxidative stress", "plddt": null, "degree": 8}, {"id": "PW:Oxidative stress", "label": "Oxidative stress", "type": "pathway", "degree": 7}, {"id": "R:Ferrostatin-1 (tool)", "label": "Ferrostatin-1 (tool)", "type": "drug", "degree": 1}, {"id": "R:Liproxstatin-1 (tool)", "label": "Liproxstatin-1 (tool)", "type": "drug", "degree": 1}, {"id": "R:ferroptosis inhibitors / selenium (investigational)", "label": "ferroptosis inhibitors / selenium (investigational)", "type": "drug", "degree": 1}, {"id": "R:ferrostatin", "label": "ferrostatin", "type": "drug", "degree": 1}, {"id": "P:IGF1", "label": "IGF1", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 59.5, "degree": 5}, {"id": "R:IGF-1 / growth-factor-based regenerative therapies (investigational)", "label": "IGF-1 / growth-factor-based regenerative therapies (investigational)", "type": "drug", "degree": 1}, {"id": "R:self-assembling IGF peptide", "label": "self-assembling IGF peptide", "type": "drug", "degree": 1}, {"id": "P:LEF1", "label": "LEF1", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Wnt/β-catenin", "plddt": 57.0, "degree": 4}, {"id": "P:PTGDS", "label": "PTGDS", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "Prostaglandin", "plddt": 87.8, "degree": 5}, {"id": "PW:Prostaglandin", "label": "Prostaglandin", "type": "pathway", "degree": 4}, {"id": "R:PGD2 pathway inhibitor", "label": "PGD2 pathway inhibitor", "type": "drug", "degree": 1}, {"id": "R:PTGDR2/CRTH2 antagonists targeting this axis (investigational)", "label": "PTGDR2/CRTH2 antagonists targeting this axis (investigational)", "type": "drug", "degree": 1}, {"id": "P:PTGFR", "label": "PTGFR", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "Prostaglandin", "plddt": 80.6, "degree": 5}, {"id": "R:bimatoprost", "label": "bimatoprost", "type": "drug", "degree": 1}, {"id": "R:latanoprost", "label": "latanoprost", "type": "drug", "degree": 1}, {"id": "P:SFRP1", "label": "SFRP1", "type": "protein", "role": "driver", "twin_node": "Wnt", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "Wnt/β-catenin", "plddt": 79.6, "degree": 7}, {"id": "R:WAY-316606 (SFRP1 inhibitor, investigational)", "label": "WAY-316606 (SFRP1 inhibitor, investigational)", "type": "drug", "degree": 1}, {"id": "R:WAY-316606 (SFRP1 inhibitor, preclinical)", "label": "WAY-316606 (SFRP1 inhibitor, preclinical)", "type": "drug", "degree": 1}, {"id": "R:WAY-316606(inhibitor)", "label": "WAY-316606(inhibitor)", "type": "drug", "degree": 1}, {"id": "R:mRNA epigenomic SFRP1 suppressor (Omega Therapeutics, preclinical)", "label": "mRNA epigenomic SFRP1 suppressor (Omega Therapeutics, preclinical)", "type": "drug", "degree": 1}, {"id": "P:SOX9", "label": "SOX9", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 1, "in_model": true, "diseases": ["AGA"], "pathway": "HFSC niche", "plddt": 56.0, "degree": 3}, {"id": "P:TGFB1", "label": "TGFB1", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 2, "in_model": true, "diseases": ["AA", "AGA", "CIA"], "pathway": "BMP/TGFβ", "plddt": 79.6, "degree": 8}, {"id": "PW:BMP/TGFβ", "label": "BMP/TGFβ", "type": "pathway", "degree": 7}, {"id": "R:Fresolimumab (anti-TGF-beta, experimental)", "label": "Fresolimumab (anti-TGF-beta, experimental)", "type": "drug", "degree": 1}, {"id": "R:TGF-beta inhibitors (investigational)", "label": "TGF-beta inhibitors (investigational)", "type": "drug", "degree": 1}, {"id": "R:TGFβ inhibitor", "label": "TGFβ inhibitor", "type": "drug", "degree": 1}, {"id": "P:FGF7", "label": "FGF7", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Growth factor", "plddt": 82.4, "degree": 6}, {"id": "R:FGF7 / growth-factor regenerative therapies (investigational)", "label": "FGF7 / growth-factor regenerative therapies (investigational)", "type": "drug", "degree": 1}, {"id": "R:Palifermin (recombinant KGF)", "label": "Palifermin (recombinant KGF)", "type": "drug", "degree": 1}, {"id": "P:SIRT1", "label": "SIRT1", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "PI3K-AKT-mTOR", "plddt": 65.0, "degree": 6}, {"id": "R:Jiawei Erzhiwan", "label": "Jiawei Erzhiwan", "type": "drug", "degree": 1}, {"id": "R:resveratrol (SIRT1 activator, investigational)", "label": "resveratrol (SIRT1 activator, investigational)", "type": "drug", "degree": 1}, {"id": "P:VDR", "label": "VDR", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 1, "in_model": true, "diseases": ["AGA", "CIA", "Other"], "pathway": "Nuclear receptor", "plddt": 83.6, "degree": 8}, {"id": "PW:Nuclear receptor", "label": "Nuclear receptor", "type": "pathway", "degree": 5}, {"id": "D:Other", "label": "Other", "type": "disease", "degree": 8}, {"id": "R:Calcitriol / vitamin D analogs (adjunctive)", "label": "Calcitriol / vitamin D analogs (adjunctive)", "type": "drug", "degree": 1}, {"id": "R:VDR gene therapy", "label": "VDR gene therapy", "type": "drug", "degree": 1}, {"id": "R:calcitriol analog", "label": "calcitriol analog", "type": "drug", "degree": 1}, {"id": "P:BMP2", "label": "BMP2", "type": "protein", "role": "modulator", "twin_node": "BMP", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "BMP/TGFβ", "plddt": 79.6, "degree": 5}, {"id": "AX:BMP", "label": "BMP/TGFβ", "type": "axis", "axis": "BMP", "degree": 7}, {"id": "R:BMP antagonists (investigational)", "label": "BMP antagonists (investigational)", "type": "drug", "degree": 2}, {"id": "P:BMP4", "label": "BMP4", "type": "protein", "role": "modulator", "twin_node": "BMP", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "BMP/TGFβ", "plddt": 78.5, "degree": 6}, {"id": "R:noggin(antagonist)", "label": "noggin(antagonist)", "type": "drug", "degree": 1}, {"id": "P:BRD4", "label": "BRD4", "type": "protein", "role": "modulator", "twin_node": "HFSC", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Epigenetic", "plddt": 55.3, "degree": 7}, {"id": "PW:Epigenetic", "label": "Epigenetic", "type": "pathway", "degree": 2}, {"id": "R:BET inhibitor", "label": "BET inhibitor", "type": "drug", "degree": 1}, {"id": "R:Birabresib", "label": "Birabresib", "type": "drug", "degree": 1}, {"id": "R:JQ1 (tool)", "label": "JQ1 (tool)", "type": "drug", "degree": 1}, {"id": "R:Molibresib", "label": "Molibresib", "type": "drug", "degree": 1}, {"id": "P:CDK4", "label": "CDK4", "type": "protein", "role": "modulator", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 86.8, "degree": 7}, {"id": "R:Abemaciclib", "label": "Abemaciclib", "type": "drug", "degree": 2}, {"id": "R:Palbociclib", "label": "Palbociclib", "type": "drug", "degree": 2}, {"id": "R:Ribociclib", "label": "Ribociclib", "type": "drug", "degree": 2}, {"id": "R:palbociclib(CDK4/6i)", "label": "palbociclib(CDK4/6i)", "type": "drug", "degree": 1}, {"id": "P:CDK6", "label": "CDK6", "type": "protein", "role": "modulator", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 85.4, "degree": 9}, {"id": "R:palbociclib", "label": "palbociclib", "type": "drug", "degree": 1}, {"id": "R:ribociclib", "label": "ribociclib", "type": "drug", "degree": 1}, {"id": "R:trilaciclib (concept for CIA)", "label": "trilaciclib (concept for CIA)", "type": "drug", "degree": 1}, {"id": "P:CRH", "label": "CRH", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "Other"], "pathway": "Stress/HPA", "plddt": 62.0, "degree": 6}, {"id": "PW:Stress/HPA", "label": "Stress/HPA", "type": "pathway", "degree": 1}, {"id": "R:Antalarmin (CRHR1 antagonist, experimental)", "label": "Antalarmin (CRHR1 antagonist, experimental)", "type": "drug", "degree": 1}, {"id": "R:astressin-B(antagonist)", "label": "astressin-B(antagonist)", "type": "drug", "degree": 1}, {"id": "P:CTLA4", "label": "CTLA4", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "Immune tolerance", "plddt": 80.1, "degree": 5}, {"id": "R:abatacept", "label": "abatacept", "type": "drug", "degree": 1}, {"id": "R:abatacept (CTLA4-Ig, investigational in AA)", "label": "abatacept (CTLA4-Ig, investigational in AA)", "type": "drug", "degree": 1}, {"id": "P:CXCL10", "label": "CXCL10", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 89.5, "degree": 3}, {"id": "P:CXCL12", "label": "CXCL12", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA", "AGA"], "pathway": "Chemokine", "plddt": 83.3, "degree": 7}, {"id": "PW:Chemokine", "label": "Chemokine", "type": "pathway", "degree": 7}, {"id": "R:AMD3100", "label": "AMD3100", "type": "drug", "degree": 1}, {"id": "R:Plerixafor (CXCR4 antagonist)", "label": "Plerixafor (CXCR4 antagonist)", "type": "drug", "degree": 1}, {"id": "R:anti-CXCL12", "label": "anti-CXCL12", "type": "drug", "degree": 1}, {"id": "P:CXCR3", "label": "CXCR3", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "Chemokine", "plddt": 80.5, "degree": 5}, {"id": "R:CXCR3 antagonist", "label": "CXCR3 antagonist", "type": "drug", "degree": 1}, {"id": "R:CXCR3 antagonists (preclinical)", "label": "CXCR3 antagonists (preclinical)", "type": "drug", "degree": 1}, {"id": "P:CXCR4", "label": "CXCR4", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA", "AGA"], "pathway": "Chemokine", "plddt": 82.3, "degree": 6}, {"id": "R:AMD3100(plerixafor)", "label": "AMD3100(plerixafor)", "type": "drug", "degree": 1}, {"id": "R:plerixafor (CXCR4 antagonist, not AA-specific)", "label": "plerixafor (CXCR4 antagonist, not AA-specific)", "type": "drug", "degree": 1}, {"id": "P:DNMT1", "label": "DNMT1", "type": "protein", "role": "modulator", "twin_node": "HFSC", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Epigenetic", "plddt": 77.8, "degree": 5}, {"id": "R:Azacitidine", "label": "Azacitidine", "type": "drug", "degree": 1}, {"id": "R:Decitabine", "label": "Decitabine", "type": "drug", "degree": 1}, {"id": "P:FGF5", "label": "FGF5", "type": "protein", "role": "modulator", "twin_node": "BMP", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Other"], "pathway": "Growth factor", "plddt": 75.7, "degree": 6}, {"id": "R:Anti-FGF5 cosmetics (unproven)", "label": "Anti-FGF5 cosmetics (unproven)", "type": "drug", "degree": 1}, {"id": "R:FGF5 inhibitor", "label": "FGF5 inhibitor", "type": "drug", "degree": 1}, {"id": "P:GAS6", "label": "GAS6", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "Growth factor", "plddt": 85.6, "degree": 6}, {"id": "D:TelogenEffluvium", "label": "TelogenEffluvium", "type": "disease", "degree": 8}, {"id": "R:GAS6 gene therapy", "label": "GAS6 gene therapy", "type": "drug", "degree": 1}, {"id": "R:recombinant GAS6 / AXL agonists (preclinical)", "label": "recombinant GAS6 / AXL agonists (preclinical)", "type": "drug", "degree": 1}, {"id": "P:GLI1", "label": "GLI1", "type": "protein", "role": "protector", "twin_node": "SHH", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Hedgehog", "plddt": 45.5, "degree": 7}, {"id": "R:Glasdegib", "label": "Glasdegib", "type": "drug", "degree": 1}, {"id": "R:Sonidegib", "label": "Sonidegib", "type": "drug", "degree": 1}, {"id": "R:Vismodegib", "label": "Vismodegib", "type": "drug", "degree": 1}, {"id": "P:HGF", "label": "HGF", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 83.5, "degree": 4}, {"id": "R:HGF-based regenerative approaches (investigational)", "label": "HGF-based regenerative approaches (investigational)", "type": "drug", "degree": 1}, {"id": "P:HMOX1", "label": "HMOX1", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Oxidative stress", "plddt": 82.9, "degree": 4}, {"id": "R:sulforaphane(Nrf2)", "label": "sulforaphane(Nrf2)", "type": "drug", "degree": 1}, {"id": "P:HR", "label": "HR", "type": "protein", "role": "modulator", "twin_node": "HFSC", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Other"], "pathway": "Nuclear receptor", "plddt": 55.2, "degree": 4}, {"id": "P:IL7R", "label": "IL7R", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 67.5, "degree": 4}, {"id": "R:anti-IL7R", "label": "anti-IL7R", "type": "drug", "degree": 1}, {"id": "P:KRT17", "label": "KRT17", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Other"], "pathway": "Structural keratin", "plddt": 77.3, "degree": 4}, {"id": "PW:Structural keratin", "label": "Structural keratin", "type": "pathway", "degree": 1}, {"id": "P:LAMA5", "label": "LAMA5", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["CIA"], "pathway": "ECM/adhesion", "plddt": 79.1, "degree": 4}, {"id": "PW:ECM/adhesion", "label": "ECM/adhesion", "type": "pathway", "degree": 1}, {"id": "R:Laminin-511-E8 fragment (experimental)", "label": "Laminin-511-E8 fragment (experimental)", "type": "drug", "degree": 1}, {"id": "P:LGR5", "label": "LGR5", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "HFSC niche", "plddt": 80.2, "degree": 3}, {"id": "P:LRP6", "label": "LRP6", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Wnt/β-catenin", "plddt": 79.2, "degree": 3}, {"id": "P:MSX2", "label": "MSX2", "type": "protein", "role": "modulator", "twin_node": "BMP", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Other"], "pathway": "BMP/TGFβ", "plddt": 67.4, "degree": 4}, {"id": "P:MTOR", "label": "MTOR", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "PI3K-AKT-mTOR", "plddt": 78.0, "degree": 4}, {"id": "R:rapamycin (mTOR inhibitor; context-dependent effects on follicle)", "label": "rapamycin (mTOR inhibitor; context-dependent effects on follicle)", "type": "drug", "degree": 1}, {"id": "P:NLRP3", "label": "NLRP3", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "Inflammasome", "plddt": 81.1, "degree": 6}, {"id": "PW:Inflammasome", "label": "Inflammasome", "type": "pathway", "degree": 2}, {"id": "R:MCC950", "label": "MCC950", "type": "drug", "degree": 1}, {"id": "R:NLRP3 inhibitors (preclinical)", "label": "NLRP3 inhibitors (preclinical)", "type": "drug", "degree": 1}, {"id": "R:total glucosides of paeony", "label": "total glucosides of paeony", "type": "drug", "degree": 1}, {"id": "P:NOG", "label": "NOG", "type": "protein", "role": "protector", "twin_node": "BMP", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "BMP/TGFβ", "plddt": 86.1, "degree": 5}, {"id": "R:recombinant noggin (investigational)", "label": "recombinant noggin (investigational)", "type": "drug", "degree": 1}, {"id": "P:NOX4", "label": "NOX4", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Oxidative stress", "plddt": 87.0, "degree": 5}, {"id": "R:ACA(NADPH oxidase 조절)", "label": "ACA(NADPH oxidase 조절)", "type": "drug", "degree": 1}, {"id": "R:NOX4 inhibitors / antioxidants (investigational)", "label": "NOX4 inhibitors / antioxidants (investigational)", "type": "drug", "degree": 1}, {"id": "P:PDGFA", "label": "PDGFA", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 78.0, "degree": 5}, {"id": "R:PRP", "label": "PRP", "type": "drug", "degree": 1}, {"id": "R:platelet-rich plasma (delivers PDGF)", "label": "platelet-rich plasma (delivers PDGF)", "type": "drug", "degree": 1}, {"id": "P:PPARG", "label": "PPARG", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Scarring"], "pathway": "Nuclear receptor", "plddt": 76.1, "degree": 7}, {"id": "R:PPARγ agonist", "label": "PPARγ agonist", "type": "drug", "degree": 1}, {"id": "R:pioglitazone", "label": "pioglitazone", "type": "drug", "degree": 1}, {"id": "R:topical PPAR-gamma agonists (investigational)", "label": "topical PPAR-gamma agonists (investigational)", "type": "drug", "degree": 1}, {"id": "P:PTCH1", "label": "PTCH1", "type": "protein", "role": "modulator", "twin_node": "SHH", "n_evidence": 0, "in_model": true, "diseases": ["CIA", "Other"], "pathway": "Hedgehog", "plddt": 73.9, "degree": 4}, {"id": "P:PTEN", "label": "PTEN", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "PI3K-AKT-mTOR", "plddt": 83.0, "degree": 3}, {"id": "P:PTGDR2", "label": "PTGDR2", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Prostaglandin", "plddt": 81.0, "degree": 9}, {"id": "R:fevipiprant", "label": "fevipiprant", "type": "drug", "degree": 2}, {"id": "R:fevipiprant (repurposing)", "label": "fevipiprant (repurposing)", "type": "drug", "degree": 1}, {"id": "R:ramatroban", "label": "ramatroban", "type": "drug", "degree": 2}, {"id": "R:setipiprant", "label": "setipiprant", "type": "drug", "degree": 1}, {"id": "R:setipiprant (CRTH2 antagonist, trialed for AGA)", "label": "setipiprant (CRTH2 antagonist, trialed for AGA)", "type": "drug", "degree": 1}, {"id": "R:setipiprant (Phase 2)", "label": "setipiprant (Phase 2)", "type": "drug", "degree": 1}, {"id": "P:RIPK1", "label": "RIPK1", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "Necroptosis", "plddt": 69.7, "degree": 5}, {"id": "PW:Necroptosis", "label": "Necroptosis", "type": "pathway", "degree": 1}, {"id": "R:RIPK1 inhibitor", "label": "RIPK1 inhibitor", "type": "drug", "degree": 1}, {"id": "R:RIPK1 inhibitors (investigational)", "label": "RIPK1 inhibitors (investigational)", "type": "drug", "degree": 1}, {"id": "P:SMAD3", "label": "SMAD3", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": true, "diseases": ["CIA"], "pathway": "BMP/TGFβ", "plddt": 83.6, "degree": 4}, {"id": "R:SIS3 (SMAD3 inhibitor, experimental)", "label": "SIS3 (SMAD3 inhibitor, experimental)", "type": "drug", "degree": 1}, {"id": "P:SOCS3", "label": "SOCS3", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 71.9, "degree": 4}, {"id": "R:SOCS3 mimetic", "label": "SOCS3 mimetic", "type": "drug", "degree": 1}, {"id": "P:SRD5A1", "label": "SRD5A1", "type": "protein", "role": "driver", "twin_node": "AND", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 91.5, "degree": 5}, {"id": "R:finasteride (weak)", "label": "finasteride (weak)", "type": "drug", "degree": 1}, {"id": "P:SRD5A3", "label": "SRD5A3", "type": "protein", "role": "modulator", "twin_node": "AND", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 88.4, "degree": 4}, {"id": "R:dutasteride (partial)", "label": "dutasteride (partial)", "type": "drug", "degree": 1}, {"id": "P:STAT5A", "label": "STAT5A", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 85.1, "degree": 3}, {"id": "P:TBX21", "label": "TBX21", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 60.9, "degree": 4}, {"id": "R:T-bet siRNA", "label": "T-bet siRNA", "type": "drug", "degree": 1}, {"id": "P:TYK2", "label": "TYK2", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": true, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 81.8, "degree": 5}, {"id": "R:deucravacitinib", "label": "deucravacitinib", "type": "drug", "degree": 1}, {"id": "R:ritlecitinib (PLCG2/JAK3 dual)", "label": "ritlecitinib (PLCG2/JAK3 dual)", "type": "drug", "degree": 1}, {"id": "P:WNT10B", "label": "WNT10B", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": true, "diseases": ["AGA"], "pathway": "Wnt/β-catenin", "plddt": 80.1, "degree": 4}, {"id": "R:Wnt mimetics (investigational)", "label": "Wnt mimetics (investigational)", "type": "drug", "degree": 1}, {"id": "P:WNT3A", "label": "WNT3A", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": true, "diseases": ["AGA", "CIA"], "pathway": "Wnt/β-catenin", "plddt": 88.3, "degree": 6}, {"id": "R:WNT agonists / GSK3 inhibitors (experimental)", "label": "WNT agonists / GSK3 inhibitors (experimental)", "type": "drug", "degree": 1}, {"id": "R:recombinant WNT3A / Wnt mimetics (investigational)", "label": "recombinant WNT3A / Wnt mimetics (investigational)", "type": "drug", "degree": 1}, {"id": "P:ABCB1", "label": "ABCB1", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 84.6, "degree": 2}, {"id": "PW:Other", "label": "Other", "type": "pathway", "degree": 35}, {"id": "P:ADM", "label": "ADM", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 61.8, "degree": 2}, {"id": "P:BAX", "label": "BAX", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 86.0, "degree": 3}, {"id": "P:BRAF", "label": "BRAF", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 66.4, "degree": 3}, {"id": "P:CASP3", "label": "CASP3", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 3, "in_model": false, "diseases": ["CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 85.8, "degree": 4}, {"id": "R:Emricasan (pan-caspase inhibitor, experimental)", "label": "Emricasan (pan-caspase inhibitor, experimental)", "type": "drug", "degree": 1}, {"id": "P:CCL26", "label": "CCL26", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Chemokine", "plddt": 84.3, "degree": 3}, {"id": "P:CCND1", "label": "CCND1", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Cell-cycle/apoptosis", "plddt": 87.3, "degree": 3}, {"id": "P:COL5A3", "label": "COL5A3", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 50.1, "degree": 2}, {"id": "P:COL6A6", "label": "COL6A6", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 74.8, "degree": 2}, {"id": "P:CRP", "label": "CRP", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 94.1, "degree": 2}, {"id": "P:CXCL9", "label": "CXCL9", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Chemokine", "plddt": 87.5, "degree": 3}, {"id": "P:CYBB", "label": "CYBB", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Oxidative stress", "plddt": 90.2, "degree": 3}, {"id": "P:DCT", "label": "DCT", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 89.1, "degree": 2}, {"id": "P:ENTPD1", "label": "ENTPD1", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 91.0, "degree": 2}, {"id": "P:ESR1", "label": "ESR1", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 2, "in_model": false, "diseases": ["AGA"], "pathway": "Nuclear receptor", "plddt": 66.4, "degree": 3}, {"id": "P:FAS", "label": "FAS", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": 77.9, "degree": 3}, {"id": "P:FGF10", "label": "FGF10", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Growth factor", "plddt": 80.0, "degree": 3}, {"id": "P:GZMH", "label": "GZMH", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Cell-cycle/apoptosis", "plddt": 92.4, "degree": 3}, {"id": "P:GZMK", "label": "GZMK", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Cell-cycle/apoptosis", "plddt": 85.4, "degree": 3}, {"id": "P:HDAC1", "label": "HDAC1", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Cell-cycle/apoptosis", "plddt": 86.2, "degree": 3}, {"id": "P:HLA-DQB1", "label": "HLA-DQB1", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 86.9, "degree": 2}, {"id": "P:HPGDS", "label": "HPGDS", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Prostaglandin", "plddt": 97.3, "degree": 3}, {"id": "P:HRH1", "label": "HRH1", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 70.0, "degree": 2}, {"id": "P:IGF1R", "label": "IGF1R", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 78.0, "degree": 3}, {"id": "P:IGHE", "label": "IGHE", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 76.5, "degree": 2}, {"id": "P:IL10", "label": "IL10", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 2, "in_model": false, "diseases": ["AA", "CIA"], "pathway": "Other", "plddt": 87.9, "degree": 3}, {"id": "P:IL13", "label": "IL13", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 85.6, "degree": 2}, {"id": "P:IL13RA1", "label": "IL13RA1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 81.6, "degree": 2}, {"id": "P:IL1B", "label": "IL1B", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 2, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 76.2, "degree": 2}, {"id": "P:IL23A", "label": "IL23A", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA", "Other"], "pathway": "Other", "plddt": 80.6, "degree": 3}, {"id": "P:IL4R", "label": "IL4R", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 2, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 54.8, "degree": 2}, {"id": "P:IL6", "label": "IL6", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 2, "in_model": false, "diseases": ["AGA", "CIA"], "pathway": "JAK-STAT", "plddt": 85.3, "degree": 4}, {"id": "P:INS", "label": "INS", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Growth factor", "plddt": 52.9, "degree": 3}, {"id": "P:KDR", "label": "KDR", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Growth factor", "plddt": 71.1, "degree": 3}, {"id": "P:KL", "label": "KL", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 89.1, "degree": 2}, {"id": "P:KLRK1", "label": "KLRK1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 79.2, "degree": 4}, {"id": "R:anti-NKG2D (investigational)", "label": "anti-NKG2D (investigational)", "type": "drug", "degree": 1}, {"id": "R:anti-NKG2D antibodies (investigational)", "label": "anti-NKG2D antibodies (investigational)", "type": "drug", "degree": 1}, {"id": "P:KRT81", "label": "KRT81", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 71.9, "degree": 2}, {"id": "P:LAMC1", "label": "LAMC1", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 76.4, "degree": 2}, {"id": "P:LAMC3", "label": "LAMC3", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 74.8, "degree": 2}, {"id": "P:MAPK1", "label": "MAPK1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 90.4, "degree": 2}, {"id": "P:MAPK8", "label": "MAPK8", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 82.4, "degree": 2}, {"id": "P:MICA", "label": "MICA", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 81.7, "degree": 2}, {"id": "P:MICB", "label": "MICB", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 78.0, "degree": 2}, {"id": "P:MKI67", "label": "MKI67", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 7, "in_model": false, "diseases": ["AGA", "CIA"], "pathway": "Cell-cycle/apoptosis", "plddt": null, "degree": 4}, {"id": "P:MYLK", "label": "MYLK", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "HFSC niche", "plddt": 65.8, "degree": 2}, {"id": "P:NCF2", "label": "NCF2", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Oxidative stress", "plddt": 78.5, "degree": 3}, {"id": "P:NFKBIZ", "label": "NFKBIZ", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Inflammasome", "plddt": 57.7, "degree": 3}, {"id": "P:NT5E", "label": "NT5E", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 2, "in_model": false, "diseases": ["AA", "AGA"], "pathway": "Other", "plddt": 91.9, "degree": 3}, {"id": "P:PAM", "label": "PAM", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 71.7, "degree": 2}, {"id": "P:PECAM1", "label": "PECAM1", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 2, "in_model": false, "diseases": ["AGA", "CIA"], "pathway": "Growth factor", "plddt": 80.4, "degree": 4}, {"id": "P:PIEZO1", "label": "PIEZO1", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "HFSC niche", "plddt": 72.0, "degree": 3}, {"id": "P:POSTN", "label": "POSTN", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "BMP/TGFβ", "plddt": 80.4, "degree": 3}, {"id": "P:PPARGC1A", "label": "PPARGC1A", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 52.7, "degree": 4}, {"id": "R:Bezafibrate", "label": "Bezafibrate", "type": "drug", "degree": 1}, {"id": "R:Metformin (indirect)", "label": "Metformin (indirect)", "type": "drug", "degree": 1}, {"id": "P:PRLR", "label": "PRLR", "type": "protein", "role": "modulator", "twin_node": "HFSC", "n_evidence": 2, "in_model": false, "diseases": ["AGA"], "pathway": "Nuclear receptor", "plddt": 61.0, "degree": 3}, {"id": "P:S100A8", "label": "S100A8", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Oxidative stress", "plddt": 93.0, "degree": 3}, {"id": "P:SOD1", "label": "SOD1", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 2, "in_model": false, "diseases": ["AGA", "CIA"], "pathway": "Oxidative stress", "plddt": 97.9, "degree": 4}, {"id": "P:SQLE", "label": "SQLE", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 85.8, "degree": 2}, {"id": "P:SREBF1", "label": "SREBF1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Other", "plddt": 63.5, "degree": 2}, {"id": "P:TAC1", "label": "TAC1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA", "AGA", "CIA", "Scarring", "TelogenEffluvium"], "pathway": "Other", "plddt": 66.9, "degree": 7}, {"id": "R:aprepitant / NK1R antagonists (concept)", "label": "aprepitant / NK1R antagonists (concept)", "type": "drug", "degree": 1}, {"id": "P:TEC", "label": "TEC", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 2, "in_model": false, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 64.2, "degree": 3}, {"id": "P:TMPRSS2", "label": "TMPRSS2", "type": "protein", "role": "driver", "twin_node": "AND", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Androgen signaling", "plddt": 79.4, "degree": 3}, {"id": "P:TNF", "label": "TNF", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 2, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 84.6, "degree": 2}, {"id": "P:TNFRSF4", "label": "TNFRSF4", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Other", "plddt": 77.0, "degree": 4}, {"id": "R:amlitelimab (anti-OX40L, repurposing concept)", "label": "amlitelimab (anti-OX40L, repurposing concept)", "type": "drug", "degree": 1}, {"id": "R:anti-OX40 antibodies (InmaGene, investigational)", "label": "anti-OX40 antibodies (InmaGene, investigational)", "type": "drug", "degree": 1}, {"id": "P:TYR", "label": "TYR", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 89.9, "degree": 2}, {"id": "P:TYRP1", "label": "TYRP1", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 1, "in_model": false, "diseases": ["CIA"], "pathway": "Other", "plddt": 91.7, "degree": 2}, {"id": "P:WNT10A", "label": "WNT10A", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 1, "in_model": false, "diseases": ["AGA"], "pathway": "Wnt/β-catenin", "plddt": 81.9, "degree": 3}, {"id": "P:XCL1", "label": "XCL1", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Chemokine", "plddt": 78.8, "degree": 3}, {"id": "P:XCL2", "label": "XCL2", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 1, "in_model": false, "diseases": ["AA"], "pathway": "Chemokine", "plddt": 80.7, "degree": 3}, {"id": "P:ATF4", "label": "ATF4", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "integrated stress response effector", "plddt": 62.0, "degree": 2}, {"id": "PW:integrated stress response effector", "label": "integrated stress response effector", "type": "pathway", "degree": 1}, {"id": "P:ATG5", "label": "ATG5", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Macroautophagy", "plddt": 93.2, "degree": 3}, {"id": "PW:Macroautophagy", "label": "Macroautophagy", "type": "pathway", "degree": 2}, {"id": "P:ATG7", "label": "ATG7", "type": "protein", "role": "protector", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Macroautophagy", "plddt": 87.6, "degree": 3}, {"id": "P:AXL", "label": "AXL", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "GAS6-AXL/TAM receptor (HFSC activation)", "plddt": 75.1, "degree": 5}, {"id": "PW:GAS6-AXL/TAM receptor (HFSC activation)", "label": "GAS6-AXL/TAM receptor (HFSC activation)", "type": "pathway", "degree": 1}, {"id": "R:AXL agonists (preclinical)", "label": "AXL agonists (preclinical)", "type": "drug", "degree": 1}, {"id": "P:BCL2L11", "label": "BCL2L11", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "intrinsic apoptosis / immune tolerance", "plddt": 60.1, "degree": 3}, {"id": "PW:intrinsic apoptosis / immune tolerance", "label": "intrinsic apoptosis / immune tolerance", "type": "pathway", "degree": 1}, {"id": "P:CALCA", "label": "CALCA", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA", "CIA"], "pathway": "Sensory neuropeptide restoration of immune privilege", "plddt": 63.9, "degree": 5}, {"id": "PW:Sensory neuropeptide restoration of immune privilege", "label": "Sensory neuropeptide restoration of immune privilege", "type": "pathway", "degree": 1}, {"id": "R:CGRP analogs / capsaicin-induced CGRP release (concept)", "label": "CGRP analogs / capsaicin-induced CGRP release (concept)", "type": "drug", "degree": 1}, {"id": "P:CASP1", "label": "CASP1", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Inflammasome/pyroptosis", "plddt": 81.7, "degree": 3}, {"id": "PW:Inflammasome/pyroptosis", "label": "Inflammasome/pyroptosis", "type": "pathway", "degree": 2}, {"id": "P:CD44", "label": "CD44", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "plddt": 53.2, "degree": 5}, {"id": "PW:Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "label": "Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "type": "pathway", "degree": 2}, {"id": "R:CD44 agonist peptides (preclinical)", "label": "CD44 agonist peptides (preclinical)", "type": "drug", "degree": 1}, {"id": "P:CD8A", "label": "CD8A", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytotoxic immunity", "plddt": 78.2, "degree": 2}, {"id": "PW:Cytotoxic immunity", "label": "Cytotoxic immunity", "type": "pathway", "degree": 2}, {"id": "P:CDKN1A", "label": "CDKN1A", "type": "protein", "role": "modulator", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "CIA"], "pathway": "Cell-cycle/apoptosis (p53)", "plddt": 69.0, "degree": 4}, {"id": "PW:Cell-cycle/apoptosis (p53)", "label": "Cell-cycle/apoptosis (p53)", "type": "pathway", "degree": 1}, {"id": "P:CDKN2A", "label": "CDKN2A", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "p16-Rb senescence", "plddt": 76.3, "degree": 5}, {"id": "PW:p16-Rb senescence", "label": "p16-Rb senescence", "type": "pathway", "degree": 1}, {"id": "R:Navitoclax", "label": "Navitoclax", "type": "drug", "degree": 1}, {"id": "R:Senolytics (Dasatinib+Quercetin)", "label": "Senolytics (Dasatinib+Quercetin)", "type": "drug", "degree": 1}, {"id": "P:CLEC16A", "label": "CLEC16A", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "autophagy / immune regulation (KIAA0350 locus)", "plddt": 70.8, "degree": 3}, {"id": "PW:autophagy / immune regulation (KIAA0350 locus)", "label": "autophagy / immune regulation (KIAA0350 locus)", "type": "pathway", "degree": 1}, {"id": "P:COL17A1", "label": "COL17A1", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "hemidesmosome basement-membrane anchorage / HFSC maintenance", "plddt": 46.9, "degree": 3}, {"id": "PW:hemidesmosome basement-membrane anchorage / HFSC maintenance", "label": "hemidesmosome basement-membrane anchorage / HFSC maintenance", "type": "pathway", "degree": 1}, {"id": "P:CXCL11", "label": "CXCL11", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "CXCR3 chemokine axis", "plddt": 80.0, "degree": 3}, {"id": "PW:CXCR3 chemokine axis", "label": "CXCR3 chemokine axis", "type": "pathway", "degree": 1}, {"id": "P:CXXC5", "label": "CXXC5", "type": "protein", "role": "driver", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "WNT/beta-catenin (negative feedback via Dishevelled)", "plddt": 59.1, "degree": 5}, {"id": "PW:WNT/beta-catenin (negative feedback via Dishevelled)", "label": "WNT/beta-catenin (negative feedback via Dishevelled)", "type": "pathway", "degree": 1}, {"id": "R:PTD-DBM (peptide, preclinical/early clinical)", "label": "PTD-DBM (peptide, preclinical/early clinical)", "type": "drug", "degree": 1}, {"id": "P:CYP1B1", "label": "CYP1B1", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "xenobiotic/estrogen metabolism (2p22 locus)", "plddt": 92.2, "degree": 2}, {"id": "PW:xenobiotic/estrogen metabolism (2p22 locus)", "label": "xenobiotic/estrogen metabolism (2p22 locus)", "type": "pathway", "degree": 1}, {"id": "P:DLX3", "label": "DLX3", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "Transcription factor", "plddt": 60.1, "degree": 2}, {"id": "PW:Transcription factor", "label": "Transcription factor", "type": "pathway", "degree": 2}, {"id": "P:EIF2AK4", "label": "EIF2AK4", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "integrated stress response (eIF2alpha-ATF4)", "plddt": 72.9, "degree": 2}, {"id": "PW:integrated stress response (eIF2alpha-ATF4)", "label": "integrated stress response (eIF2alpha-ATF4)", "type": "pathway", "degree": 1}, {"id": "P:EZH2", "label": "EZH2", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "PRC2 / H3K27me3 repression", "plddt": 76.2, "degree": 4}, {"id": "PW:PRC2 / H3K27me3 repression", "label": "PRC2 / H3K27me3 repression", "type": "pathway", "degree": 1}, {"id": "R:GSK126 (tool)", "label": "GSK126 (tool)", "type": "drug", "degree": 1}, {"id": "R:Tazemetostat", "label": "Tazemetostat", "type": "drug", "degree": 1}, {"id": "P:F11R", "label": "F11R", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Tight-junction adhesion / barrier", "plddt": 87.2, "degree": 3}, {"id": "PW:Tight-junction adhesion / barrier", "label": "Tight-junction adhesion / barrier", "type": "pathway", "degree": 1}, {"id": "P:F2R", "label": "F2R", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "protease-activated receptor signaling in dermal papilla", "plddt": 74.6, "degree": 2}, {"id": "PW:protease-activated receptor signaling in dermal papilla", "label": "protease-activated receptor signaling in dermal papilla", "type": "pathway", "degree": 1}, {"id": "P:FOXN1", "label": "FOXN1", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "Transcription factor", "plddt": 53.7, "degree": 2}, {"id": "P:GSDMD", "label": "GSDMD", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Inflammasome/pyroptosis", "plddt": 77.8, "degree": 4}, {"id": "R:disulfiram (GSDMD inhibitor, investigational)", "label": "disulfiram (GSDMD inhibitor, investigational)", "type": "drug", "degree": 1}, {"id": "P:GZMA", "label": "GZMA", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "cytotoxic T-cell - dermal papilla crosstalk (GZMA-F2R)", "plddt": 91.6, "degree": 3}, {"id": "PW:cytotoxic T-cell - dermal papilla crosstalk (GZMA-F2R)", "label": "cytotoxic T-cell - dermal papilla crosstalk (GZMA-F2R)", "type": "pathway", "degree": 1}, {"id": "P:GZMB", "label": "GZMB", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytotoxic immunity", "plddt": 92.4, "degree": 2}, {"id": "P:HCAR2", "label": "HCAR2", "type": "protein", "role": "modulator", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "PGD2-GPR44(CRTH2/PTGDR2) inhibition of hair growth", "plddt": 82.7, "degree": 6}, {"id": "PW:PGD2-GPR44(CRTH2/PTGDR2) inhibition of hair growth", "label": "PGD2-GPR44(CRTH2/PTGDR2) inhibition of hair growth", "type": "pathway", "degree": 1}, {"id": "R:setipiprant (Phase 2, AGA)", "label": "setipiprant (Phase 2, AGA)", "type": "drug", "degree": 1}, {"id": "P:HLA-B", "label": "HLA-B", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "MHC class I antigen presentation (6p21 locus)", "plddt": 88.1, "degree": 3}, {"id": "PW:MHC class I antigen presentation (6p21 locus)", "label": "MHC class I antigen presentation (6p21 locus)", "type": "pathway", "degree": 1}, {"id": "P:IFNGR1", "label": "IFNGR1", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Type II interferon", "plddt": 66.0, "degree": 3}, {"id": "PW:Type II interferon", "label": "Type II interferon", "type": "pathway", "degree": 1}, {"id": "P:IKZF4", "label": "IKZF4", "type": "protein", "role": "modulator", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "FOXP3 transcriptional program / Treg stability", "plddt": 49.0, "degree": 2}, {"id": "PW:FOXP3 transcriptional program / Treg stability", "label": "FOXP3 transcriptional program / Treg stability", "type": "pathway", "degree": 1}, {"id": "P:IL15RA", "label": "IL15RA", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytokine (common gamma chain)", "plddt": 64.5, "degree": 3}, {"id": "PW:Cytokine (common gamma chain)", "label": "Cytokine (common gamma chain)", "type": "pathway", "degree": 4}, {"id": "P:IL2", "label": "IL2", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytokine (common gamma chain)", "plddt": 84.1, "degree": 4}, {"id": "R:low-dose IL-2 / aldesleukin (investigational)", "label": "low-dose IL-2 / aldesleukin (investigational)", "type": "drug", "degree": 1}, {"id": "P:IL21", "label": "IL21", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Tfh/Th17 cytokine signaling (IL2/IL21 locus)", "plddt": 83.4, "degree": 3}, {"id": "PW:Tfh/Th17 cytokine signaling (IL2/IL21 locus)", "label": "Tfh/Th17 cytokine signaling (IL2/IL21 locus)", "type": "pathway", "degree": 1}, {"id": "P:IL2RB", "label": "IL2RB", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Low-dose/PEG-IL-2 -> Treg expansion (tolerance restoration)", "plddt": 64.6, "degree": 4}, {"id": "PW:Low-dose/PEG-IL-2 -> Treg expansion (tolerance restoration)", "label": "Low-dose/PEG-IL-2 -> Treg expansion (tolerance restoration)", "type": "pathway", "degree": 1}, {"id": "R:rezpegaldesleukin (Nektar NKTR-358, Phase 2, Fast Track)", "label": "rezpegaldesleukin (Nektar NKTR-358, Phase 2, Fast Track)", "type": "drug", "degree": 1}, {"id": "P:IL2RG", "label": "IL2RG", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytokine (common gamma chain)", "plddt": 75.5, "degree": 4}, {"id": "R:ritlecitinib (via JAK3)", "label": "ritlecitinib (via JAK3)", "type": "drug", "degree": 1}, {"id": "P:IL7", "label": "IL7", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Cytokine (common gamma chain)", "plddt": 73.9, "degree": 3}, {"id": "P:IL9", "label": "IL9", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "Th9 / mast-cell cytokine signaling (gamma-chain)", "plddt": 84.1, "degree": 3}, {"id": "PW:Th9 / mast-cell cytokine signaling (gamma-chain)", "label": "Th9 / mast-cell cytokine signaling (gamma-chain)", "type": "pathway", "degree": 1}, {"id": "P:KRT15", "label": "KRT15", "type": "protein", "role": "modulator", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Bulge HFSC intermediate-filament marker", "plddt": 74.2, "degree": 3}, {"id": "PW:Bulge HFSC intermediate-filament marker", "label": "Bulge HFSC intermediate-filament marker", "type": "pathway", "degree": 1}, {"id": "P:KRT75", "label": "KRT75", "type": "protein", "role": "modulator", "twin_node": "DP", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "Keratin/structural", "plddt": 67.3, "degree": 3}, {"id": "PW:Keratin/structural", "label": "Keratin/structural", "type": "pathway", "degree": 1}, {"id": "P:LDHA", "label": "LDHA", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Glycolytic lactate metabolism", "plddt": 96.2, "degree": 4}, {"id": "PW:Glycolytic lactate metabolism", "label": "Glycolytic lactate metabolism", "type": "pathway", "degree": 1}, {"id": "R:FX11 (experimental)", "label": "FX11 (experimental)", "type": "drug", "degree": 1}, {"id": "R:Oxamate (experimental)", "label": "Oxamate (experimental)", "type": "drug", "degree": 1}, {"id": "P:LGR6", "label": "LGR6", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "WNT/R-spondin potentiation", "plddt": 77.4, "degree": 3}, {"id": "PW:WNT/R-spondin potentiation", "label": "WNT/R-spondin potentiation", "type": "pathway", "degree": 1}, {"id": "P:LRP5", "label": "LRP5", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Wnt/beta-catenin", "plddt": 77.9, "degree": 3}, {"id": "PW:Wnt/beta-catenin", "label": "Wnt/beta-catenin", "type": "pathway", "degree": 1}, {"id": "P:LRRC32", "label": "LRRC32", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "TGF-beta latency / regulatory T-cell function", "plddt": 86.1, "degree": 3}, {"id": "PW:TGF-beta latency / regulatory T-cell function", "label": "TGF-beta latency / regulatory T-cell function", "type": "pathway", "degree": 1}, {"id": "P:MMP9", "label": "MMP9", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "extracellular matrix remodeling / fibrosis", "plddt": 82.1, "degree": 3}, {"id": "PW:extracellular matrix remodeling / fibrosis", "label": "extracellular matrix remodeling / fibrosis", "type": "pathway", "degree": 1}, {"id": "P:MPC1", "label": "MPC1", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "mitochondrial pyruvate import / glycolytic HFSC activation", "plddt": 92.8, "degree": 3}, {"id": "PW:mitochondrial pyruvate import / glycolytic HFSC activation", "label": "mitochondrial pyruvate import / glycolytic HFSC activation", "type": "pathway", "degree": 1}, {"id": "P:MSR1", "label": "MSR1", "type": "protein", "role": "driver", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["lichen planopilaris / CCCA"], "pathway": "M2 macrophage-mediated fibrosis / lipid scavenging", "plddt": 67.4, "degree": 3}, {"id": "PW:M2 macrophage-mediated fibrosis / lipid scavenging", "label": "M2 macrophage-mediated fibrosis / lipid scavenging", "type": "pathway", "degree": 1}, {"id": "D:lichen planopilaris / CCCA", "label": "lichen planopilaris / CCCA", "type": "disease", "degree": 1}, {"id": "P:NFATC1", "label": "NFATC1", "type": "protein", "role": "modulator", "twin_node": "BMP", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "BMP-NFATc1 quiescence control", "plddt": 56.8, "degree": 5}, {"id": "PW:BMP-NFATc1 quiescence control", "label": "BMP-NFATc1 quiescence control", "type": "pathway", "degree": 1}, {"id": "R:Cyclosporine A", "label": "Cyclosporine A", "type": "drug", "degree": 1}, {"id": "R:Tacrolimus", "label": "Tacrolimus", "type": "drug", "degree": 1}, {"id": "P:OSM", "label": "OSM", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "OSM/OSMR -> JAK2-STAT5 (HFSC quiescence)", "plddt": 78.7, "degree": 5}, {"id": "PW:OSM/OSMR -> JAK2-STAT5 (HFSC quiescence)", "label": "OSM/OSMR -> JAK2-STAT5 (HFSC quiescence)", "type": "pathway", "degree": 1}, {"id": "R:OSM/OSMR-targeting antibodies (in development for other indications)", "label": "OSM/OSMR-targeting antibodies (in development for other indications)", "type": "drug", "degree": 1}, {"id": "P:PADI3", "label": "PADI3", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "hair-shaft protein citrullination / inner root sheath integrity", "plddt": 93.7, "degree": 2}, {"id": "PW:hair-shaft protein citrullination / inner root sheath integrity", "label": "hair-shaft protein citrullination / inner root sheath integrity", "type": "pathway", "degree": 1}, {"id": "P:PTH1R", "label": "PTH1R", "type": "protein", "role": "protector", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "GPCR (PTH/PTHrP)", "plddt": 71.0, "degree": 4}, {"id": "PW:GPCR (PTH/PTHrP)", "label": "GPCR (PTH/PTHrP)", "type": "pathway", "degree": 1}, {"id": "R:Abaloparatide / Teriparatide (PTH1R agonists)", "label": "Abaloparatide / Teriparatide (PTH1R agonists)", "type": "drug", "degree": 1}, {"id": "R:PTH-CBD (collagen-binding PTH agonist)", "label": "PTH-CBD (collagen-binding PTH agonist)", "type": "drug", "degree": 1}, {"id": "P:S100A3", "label": "S100A3", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "PADI3 substrate / cuticle calcium signaling", "plddt": 81.5, "degree": 2}, {"id": "PW:PADI3 substrate / cuticle calcium signaling", "label": "PADI3 substrate / cuticle calcium signaling", "type": "pathway", "degree": 1}, {"id": "P:SCUBE3", "label": "SCUBE3", "type": "protein", "role": "protector", "twin_node": "BMP", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "TGF-beta/SHH activation (dermal papilla anagen signal)", "plddt": 77.1, "degree": 5}, {"id": "PW:TGF-beta/SHH activation (dermal papilla anagen signal)", "label": "TGF-beta/SHH activation (dermal papilla anagen signal)", "type": "pathway", "degree": 1}, {"id": "R:AMP-126", "label": "AMP-126", "type": "drug", "degree": 1}, {"id": "R:AMP-303 (Amplifica, Phase 1/2)", "label": "AMP-303 (Amplifica, Phase 1/2)", "type": "drug", "degree": 1}, {"id": "P:SFRP4", "label": "SFRP4", "type": "protein", "role": "driver", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "Wnt antagonism / fibrosis", "plddt": 78.4, "degree": 3}, {"id": "PW:Wnt antagonism / fibrosis", "label": "Wnt antagonism / fibrosis", "type": "pathway", "degree": 1}, {"id": "P:SH2B3", "label": "SH2B3", "type": "protein", "role": "modulator", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "JAK-STAT negative regulation / cytokine signaling", "plddt": 62.1, "degree": 3}, {"id": "PW:JAK-STAT negative regulation / cytokine signaling", "label": "JAK-STAT negative regulation / cytokine signaling", "type": "pathway", "degree": 1}, {"id": "P:SOCS1", "label": "SOCS1", "type": "protein", "role": "protector", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "JAK-STAT negative feedback", "plddt": 83.1, "degree": 3}, {"id": "PW:JAK-STAT negative feedback", "label": "JAK-STAT negative feedback", "type": "pathway", "degree": 1}, {"id": "P:SPP1", "label": "SPP1", "type": "protein", "role": "protector", "twin_node": "HFSC", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "plddt": 53.4, "degree": 5}, {"id": "R:recombinant osteopontin / OPN peptides (preclinical)", "label": "recombinant osteopontin / OPN peptides (preclinical)", "type": "drug", "degree": 1}, {"id": "P:SQSTM1", "label": "SQSTM1", "type": "protein", "role": "modulator", "twin_node": "APO", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Selective autophagy / KEAP1-NRF2 stress", "plddt": 67.2, "degree": 3}, {"id": "PW:Selective autophagy / KEAP1-NRF2 stress", "label": "Selective autophagy / KEAP1-NRF2 stress", "type": "pathway", "degree": 1}, {"id": "P:STAT5B", "label": "STAT5B", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "JAK-STAT", "plddt": 85.2, "degree": 3}, {"id": "P:TCF3", "label": "TCF3", "type": "protein", "role": "modulator", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "WNT/TCF stemness repression", "plddt": 51.8, "degree": 3}, {"id": "PW:WNT/TCF stemness repression", "label": "WNT/TCF stemness repression", "type": "pathway", "degree": 1}, {"id": "P:TCF7", "label": "TCF7", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "WNT/beta-catenin effector", "plddt": 57.1, "degree": 3}, {"id": "PW:WNT/beta-catenin effector", "label": "WNT/beta-catenin effector", "type": "pathway", "degree": 1}, {"id": "P:TCHH", "label": "TCHH", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["CIA"], "pathway": "PADI3 substrate / inner root sheath cornification", "plddt": 67.6, "degree": 2}, {"id": "PW:PADI3 substrate / inner root sheath cornification", "label": "PADI3 substrate / inner root sheath cornification", "type": "pathway", "degree": 1}, {"id": "P:TLR2", "label": "TLR2", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "innate immune sensing of microbiome lipids / NLRP3 priming", "plddt": 87.9, "degree": 3}, {"id": "PW:innate immune sensing of microbiome lipids / NLRP3 priming", "label": "innate immune sensing of microbiome lipids / NLRP3 priming", "type": "pathway", "degree": 1}, {"id": "P:TREM2", "label": "TREM2", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AGA", "TelogenEffluvium"], "pathway": "TREM2+ macrophage / Oncostatin M -> JAK-STAT5 (HFSC quiescence)", "plddt": 76.8, "degree": 5}, {"id": "PW:TREM2+ macrophage / Oncostatin M -> JAK-STAT5 (HFSC quiescence)", "label": "TREM2+ macrophage / Oncostatin M -> JAK-STAT5 (HFSC quiescence)", "type": "pathway", "degree": 1}, {"id": "R:anti-OSM / OSMR blockade (conceptual)", "label": "anti-OSM / OSMR blockade (conceptual)", "type": "drug", "degree": 1}, {"id": "P:TRPS1", "label": "TRPS1", "type": "protein", "role": "protector", "twin_node": "Wnt", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Wnt regulation downstream of YAP inhibition", "plddt": 48.5, "degree": 3}, {"id": "PW:Wnt regulation downstream of YAP inhibition", "label": "Wnt regulation downstream of YAP inhibition", "type": "pathway", "degree": 1}, {"id": "P:TSLP", "label": "TSLP", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "epithelial alarmin / IL-7R-TSLPR signaling", "plddt": 79.1, "degree": 3}, {"id": "PW:epithelial alarmin / IL-7R-TSLPR signaling", "label": "epithelial alarmin / IL-7R-TSLPR signaling", "type": "pathway", "degree": 1}, {"id": "P:ULBP3", "label": "ULBP3", "type": "protein", "role": "driver", "twin_node": "INF", "n_evidence": 0, "in_model": false, "diseases": ["AA"], "pathway": "NKG2D innate cytotoxicity / immune-privilege collapse", "plddt": 81.6, "degree": 3}, {"id": "PW:NKG2D innate cytotoxicity / immune-privilege collapse", "label": "NKG2D innate cytotoxicity / immune-privilege collapse", "type": "pathway", "degree": 1}, {"id": "P:VCAN", "label": "VCAN", "type": "protein", "role": "protector", "twin_node": "DP", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Dermal-papilla ECM / inductivity", "plddt": 85.1, "degree": 3}, {"id": "PW:Dermal-papilla ECM / inductivity", "label": "Dermal-papilla ECM / inductivity", "type": "pathway", "degree": 1}, {"id": "P:YAP1", "label": "YAP1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "Hippo / mechanotransduction in connective tissue sheath", "plddt": 57.4, "degree": 2}, {"id": "PW:Hippo / mechanotransduction in connective tissue sheath", "label": "Hippo / mechanotransduction in connective tissue sheath", "type": "pathway", "degree": 1}, {"id": "P:ZEB1", "label": "ZEB1", "type": "protein", "role": "driver", "twin_node": "—", "n_evidence": 0, "in_model": false, "diseases": ["AGA"], "pathway": "EMT / fibrotic remodeling", "plddt": 47.9, "degree": 2}, {"id": "PW:EMT / fibrotic remodeling", "label": "EMT / fibrotic remodeling", "type": "pathway", "degree": 1}], "links": [{"type": "in_pathway", "source": "P:CTNNB1", "target": "PW:Wnt/β-catenin"}, {"type": "associated_with", "source": "P:CTNNB1", "target": "D:AA"}, {"type": "associated_with", "source": "P:CTNNB1", "target": "D:AGA"}, {"type": "associated_with", "source": "P:CTNNB1", "target": "D:CIA"}, {"type": "maps_to_axis", "effect": "+", "source": "P:CTNNB1", "target": "AX:Wnt"}, {"type": "targeted_by", "source": "P:CTNNB1", "target": "R:Wnt agonist"}, {"type": "targeted_by", "source": "P:CTNNB1", "target": "R:Wnt/beta-catenin agonists (investigational)"}, {"type": "targeted_by", "source": "P:CTNNB1", "target": "R:valproate"}, {"type": "targeted_by", "source": "P:CTNNB1", "target": "R:valproic acid (GSK3 inhibition, off-label)"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:DKK1"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:LEF1"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:SFRP1"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:LRP6"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:WNT10B"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:WNT3A"}, {"type": "in_pathway", "source": "PW:Wnt/β-catenin", "target": "P:WNT10A"}, {"type": "associated_with", "source": "D:AA", "target": "P:VEGFA"}, {"type": "associated_with", "source": "D:AA", "target": "P:IFNG"}, {"type": "associated_with", "source": "D:AA", "target": "P:STAT3"}, {"type": "associated_with", "source": "D:AA", "target": "P:AKT1"}, {"type": "associated_with", "source": "D:AA", "target": "P:DKK1"}, {"type": "associated_with", "source": "D:AA", "target": "P:FOXP3"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL15"}, {"type": "associated_with", "source": "D:AA", "target": "P:JAK1"}, {"type": "associated_with", "source": "D:AA", "target": "P:JAK2"}, {"type": "associated_with", "source": "D:AA", "target": "P:JAK3"}, {"type": "associated_with", "source": "D:AA", "target": "P:STAT1"}, {"type": "associated_with", "source": "D:AA", "target": "P:TGFB1"}, {"type": "associated_with", "source": "D:AA", "target": "P:CTLA4"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCL10"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCL12"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCR3"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCR4"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL7R"}, {"type": "associated_with", "source": "D:AA", "target": "P:NLRP3"}, {"type": "associated_with", "source": "D:AA", "target": "P:RIPK1"}, {"type": "associated_with", "source": "D:AA", "target": "P:SOCS3"}, {"type": "associated_with", "source": "D:AA", "target": "P:STAT5A"}, {"type": "associated_with", "source": "D:AA", "target": "P:TBX21"}, {"type": "associated_with", "source": "D:AA", "target": "P:TYK2"}, {"type": "associated_with", "source": "D:AA", "target": "P:CCL26"}, {"type": "associated_with", "source": "D:AA", "target": "P:COL5A3"}, {"type": "associated_with", "source": "D:AA", "target": "P:COL6A6"}, {"type": "associated_with", "source": "D:AA", "target": "P:CRP"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCL9"}, {"type": "associated_with", "source": "D:AA", "target": "P:ENTPD1"}, {"type": "associated_with", "source": "D:AA", "target": "P:GZMH"}, {"type": "associated_with", "source": "D:AA", "target": "P:GZMK"}, {"type": "associated_with", "source": "D:AA", "target": "P:IGHE"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL10"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL13"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL13RA1"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL23A"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL4R"}, {"type": "associated_with", "source": "D:AA", "target": "P:KLRK1"}, {"type": "associated_with", "source": "D:AA", "target": "P:MICA"}, {"type": "associated_with", "source": "D:AA", "target": "P:MICB"}, {"type": "associated_with", "source": "D:AA", "target": "P:NT5E"}, {"type": "associated_with", "source": "D:AA", "target": "P:POSTN"}, {"type": "associated_with", "source": "D:AA", "target": "P:TAC1"}, {"type": "associated_with", "source": "D:AA", "target": "P:TEC"}, {"type": "associated_with", "source": "D:AA", "target": "P:TNFRSF4"}, {"type": "associated_with", "source": "D:AA", "target": "P:XCL1"}, {"type": "associated_with", "source": "D:AA", "target": "P:XCL2"}, {"type": "associated_with", "source": "D:AA", "target": "P:BCL2L11"}, {"type": "associated_with", "source": "D:AA", "target": "P:CALCA"}, {"type": "associated_with", "source": "D:AA", "target": "P:CASP1"}, {"type": "associated_with", "source": "D:AA", "target": "P:CD8A"}, {"type": "associated_with", "source": "D:AA", "target": "P:CLEC16A"}, {"type": "associated_with", "source": "D:AA", "target": "P:CXCL11"}, {"type": "associated_with", "source": "D:AA", "target": "P:F2R"}, {"type": "associated_with", "source": "D:AA", "target": "P:GSDMD"}, {"type": "associated_with", "source": "D:AA", "target": "P:GZMA"}, {"type": "associated_with", "source": "D:AA", "target": "P:GZMB"}, {"type": "associated_with", "source": "D:AA", "target": "P:IFNGR1"}, {"type": "associated_with", "source": "D:AA", "target": "P:IKZF4"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL15RA"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL2"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL21"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL2RB"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL2RG"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL7"}, {"type": "associated_with", "source": "D:AA", "target": "P:IL9"}, {"type": "associated_with", "source": "D:AA", "target": "P:LRRC32"}, {"type": "associated_with", "source": "D:AA", "target": "P:SH2B3"}, {"type": "associated_with", "source": "D:AA", "target": "P:SOCS1"}, {"type": "associated_with", "source": "D:AA", "target": "P:STAT5B"}, {"type": "associated_with", "source": "D:AA", "target": "P:TSLP"}, {"type": "associated_with", "source": "D:AA", "target": "P:ULBP3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:AR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SRD5A2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:VEGFA"}, {"type": "associated_with", "source": "D:AGA", "target": "P:BCL2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:STAT3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TP53"}, {"type": "associated_with", "source": "D:AGA", "target": "P:AKT1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CD34"}, {"type": "associated_with", "source": "D:AGA", "target": "P:DKK1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SHH"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CYP19A1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:EGFR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:GPX4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:IGF1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LEF1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PTGDS"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PTGFR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SFRP1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SOX9"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TGFB1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:FGF7"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SIRT1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:VDR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:BMP2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:BMP4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:BRD4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CRH"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CXCL12"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CXCR4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:DNMT1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:GAS6"}, {"type": "associated_with", "source": "D:AGA", "target": "P:GLI1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HGF"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HMOX1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LGR5"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LRP6"}, {"type": "associated_with", "source": "D:AGA", "target": "P:MTOR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:NOG"}, {"type": "associated_with", "source": "D:AGA", "target": "P:NOX4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PDGFA"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PTEN"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PTGDR2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SRD5A1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SRD5A3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:WNT10B"}, {"type": "associated_with", "source": "D:AGA", "target": "P:WNT3A"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ADM"}, {"type": "associated_with", "source": "D:AGA", "target": "P:BRAF"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CCND1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ESR1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HDAC1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HPGDS"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HRH1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:IGF1R"}, {"type": "associated_with", "source": "D:AGA", "target": "P:IL6"}, {"type": "associated_with", "source": "D:AGA", "target": "P:INS"}, {"type": "associated_with", "source": "D:AGA", "target": "P:KL"}, {"type": "associated_with", "source": "D:AGA", "target": "P:KRT81"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LAMC1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LAMC3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:MAPK1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:MKI67"}, {"type": "associated_with", "source": "D:AGA", "target": "P:MYLK"}, {"type": "associated_with", "source": "D:AGA", "target": "P:NFKBIZ"}, {"type": "associated_with", "source": "D:AGA", "target": "P:NT5E"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PAM"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PECAM1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PIEZO1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PPARGC1A"}, {"type": "associated_with", "source": "D:AGA", "target": "P:PRLR"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SOD1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SQLE"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SREBF1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TAC1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TMPRSS2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:WNT10A"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ATF4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ATG5"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ATG7"}, {"type": "associated_with", "source": "D:AGA", "target": "P:AXL"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CD44"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CDKN1A"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CDKN2A"}, {"type": "associated_with", "source": "D:AGA", "target": "P:COL17A1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:CXXC5"}, {"type": "associated_with", "source": "D:AGA", "target": "P:EIF2AK4"}, {"type": "associated_with", "source": "D:AGA", "target": "P:EZH2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:F11R"}, {"type": "associated_with", "source": "D:AGA", "target": "P:HCAR2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:KRT15"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LDHA"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LGR6"}, {"type": "associated_with", "source": "D:AGA", "target": "P:LRP5"}, {"type": "associated_with", "source": "D:AGA", "target": "P:MPC1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:NFATC1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:OSM"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SCUBE3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SPP1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:SQSTM1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TCF3"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TCF7"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TLR2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TREM2"}, {"type": "associated_with", "source": "D:AGA", "target": "P:TRPS1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:VCAN"}, {"type": "associated_with", "source": "D:AGA", "target": "P:YAP1"}, {"type": "associated_with", "source": "D:AGA", "target": "P:ZEB1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:VEGFA"}, {"type": "associated_with", "source": "D:CIA", "target": "P:BCL2"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TP53"}, {"type": "associated_with", "source": "D:CIA", "target": "P:AKT1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CD34"}, {"type": "associated_with", "source": "D:CIA", "target": "P:JAK1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:SHH"}, {"type": "associated_with", "source": "D:CIA", "target": "P:STAT1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:EGFR"}, {"type": "associated_with", "source": "D:CIA", "target": "P:GPX4"}, {"type": "associated_with", "source": "D:CIA", "target": "P:LEF1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TGFB1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:FGF7"}, {"type": "associated_with", "source": "D:CIA", "target": "P:SIRT1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:VDR"}, {"type": "associated_with", "source": "D:CIA", "target": "P:BMP2"}, {"type": "associated_with", "source": "D:CIA", "target": "P:BMP4"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CDK4"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CDK6"}, {"type": "associated_with", "source": "D:CIA", "target": "P:FGF5"}, {"type": "associated_with", "source": "D:CIA", "target": "P:GLI1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:HR"}, {"type": "associated_with", "source": "D:CIA", "target": "P:KRT17"}, {"type": "associated_with", "source": "D:CIA", "target": "P:LAMA5"}, {"type": "associated_with", "source": "D:CIA", "target": "P:MSX2"}, {"type": "associated_with", "source": "D:CIA", "target": "P:NOG"}, {"type": "associated_with", "source": "D:CIA", "target": "P:PPARG"}, {"type": "associated_with", "source": "D:CIA", "target": "P:PTCH1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:SMAD3"}, {"type": "associated_with", "source": "D:CIA", "target": "P:WNT3A"}, {"type": "associated_with", "source": "D:CIA", "target": "P:ABCB1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:BAX"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CASP3"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CYBB"}, {"type": "associated_with", "source": "D:CIA", "target": "P:DCT"}, {"type": "associated_with", "source": "D:CIA", "target": "P:FAS"}, {"type": "associated_with", "source": "D:CIA", "target": "P:FGF10"}, {"type": "associated_with", "source": "D:CIA", "target": "P:HLA-DQB1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:IL10"}, {"type": "associated_with", "source": "D:CIA", "target": "P:IL1B"}, {"type": "associated_with", "source": "D:CIA", "target": "P:IL6"}, {"type": "associated_with", "source": "D:CIA", "target": "P:KDR"}, {"type": "associated_with", "source": "D:CIA", "target": "P:MAPK8"}, {"type": "associated_with", "source": "D:CIA", "target": "P:MKI67"}, {"type": "associated_with", "source": "D:CIA", "target": "P:NCF2"}, {"type": "associated_with", "source": "D:CIA", "target": "P:PECAM1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:S100A8"}, {"type": "associated_with", "source": "D:CIA", "target": "P:SOD1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TAC1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TNF"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TYR"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TYRP1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CALCA"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CDKN1A"}, {"type": "associated_with", "source": "D:CIA", "target": "P:CYP1B1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:DLX3"}, {"type": "associated_with", "source": "D:CIA", "target": "P:FOXN1"}, {"type": "associated_with", "source": "D:CIA", "target": "P:HLA-B"}, {"type": "associated_with", "source": "D:CIA", "target": "P:KRT75"}, {"type": "associated_with", "source": "D:CIA", "target": "P:MMP9"}, {"type": "associated_with", "source": "D:CIA", "target": "P:PADI3"}, {"type": "associated_with", "source": "D:CIA", "target": "P:PTH1R"}, {"type": "associated_with", "source": "D:CIA", "target": "P:S100A3"}, {"type": "associated_with", "source": "D:CIA", "target": "P:SFRP4"}, {"type": "associated_with", "source": "D:CIA", "target": "P:TCHH"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:Wnt", "target": "P:DKK1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:LEF1"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:Wnt", "target": "P:SFRP1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:LRP6"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:WNT10B"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:WNT3A"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:WNT10A"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:Wnt", "target": "P:CXXC5"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:LGR6"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:LRP5"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:Wnt", "target": "P:SFRP4"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:Wnt", "target": "P:TCF3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:TCF7"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:Wnt", "target": "P:TRPS1"}, {"type": "in_pathway", "source": "P:AR", "target": "PW:Androgen signaling"}, {"type": "maps_to_axis", "effect": "+", "source": "P:AR", "target": "AX:AND"}, {"type": "targeted_by", "source": "P:AR", "target": "R:GT20029 (Kintor, topical AR-PROTAC, Phase 2)"}, {"type": "targeted_by", "source": "P:AR", "target": "R:RU58841"}, {"type": "targeted_by", "source": "P:AR", "target": "R:RU58841 (clascoterone-class topical antiandrogens)"}, {"type": "targeted_by", "source": "P:AR", "target": "R:bicalutamide"}, {"type": "targeted_by", "source": "P:AR", "target": "R:clascoterone"}, {"type": "targeted_by", "source": "P:AR", "target": "R:dutasteride (indirect)"}, {"type": "in_pathway", "source": "PW:Androgen signaling", "target": "P:SRD5A2"}, {"type": "in_pathway", "source": "PW:Androgen signaling", "target": "P:CYP19A1"}, {"type": "in_pathway", "source": "PW:Androgen signaling", "target": "P:SRD5A1"}, {"type": "in_pathway", "source": "PW:Androgen signaling", "target": "P:SRD5A3"}, {"type": "in_pathway", "source": "PW:Androgen signaling", "target": "P:TMPRSS2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:AND", "target": "P:SRD5A2"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:AND", "target": "P:CYP19A1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:AND", "target": "P:SRD5A1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:AND", "target": "P:SRD5A3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:AND", "target": "P:TMPRSS2"}, {"type": "targeted_by", "source": "P:SRD5A2", "target": "R:dutasteride"}, {"type": "targeted_by", "source": "P:SRD5A2", "target": "R:finasteride"}, {"type": "targeted_by", "source": "R:dutasteride", "target": "P:SRD5A1"}, {"type": "in_pathway", "source": "P:VEGFA", "target": "PW:Growth factor"}, {"type": "maps_to_axis", "effect": "+", "source": "P:VEGFA", "target": "AX:DP"}, {"type": "targeted_by", "source": "P:VEGFA", "target": "R:VEGF microneedle"}, {"type": "targeted_by", "source": "P:VEGFA", "target": "R:minoxidil (upregulates VEGFA)"}, {"type": "targeted_by", "source": "P:VEGFA", "target": "R:minoxidil(indirect)"}, {"type": "targeted_by", "source": "P:VEGFA", "target": "R:platelet-rich plasma (delivers VEGFA)"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:EGFR"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:IGF1"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:FGF7"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:FGF5"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:GAS6"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:HGF"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:PDGFA"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:BRAF"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:FGF10"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:IGF1R"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:INS"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:KDR"}, {"type": "in_pathway", "source": "PW:Growth factor", "target": "P:PECAM1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:AKT1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:EGFR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:IGF1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:PTGFR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:FGF7"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:SIRT1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:GAS6"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:HGF"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:KRT17"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:LAMA5"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:MTOR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:PDGFA"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:DP", "target": "P:BRAF"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:CCND1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:FGF10"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:IGF1R"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:DP", "target": "P:INS"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:KDR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:PECAM1"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:DP", "target": "P:F11R"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:DP", "target": "P:KRT75"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:DP", "target": "P:VCAN"}, {"type": "in_pathway", "source": "P:BCL2", "target": "PW:Cell-cycle/apoptosis"}, {"type": "maps_to_axis", "effect": "-", "source": "P:BCL2", "target": "AX:APO"}, {"type": "targeted_by", "source": "P:BCL2", "target": "R:Venetoclax (BCL2 inhibitor; opposing context)"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:TP53"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:CDK4"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:CDK6"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:BAX"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:CASP3"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:CCND1"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:FAS"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:GZMH"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:GZMK"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:HDAC1"}, {"type": "in_pathway", "source": "PW:Cell-cycle/apoptosis", "target": "P:MKI67"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:TP53"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:GPX4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:PTGDS"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:TGFB1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CDK4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CDK6"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CRH"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:HMOX1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:NOX4"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:PTEN"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:PTGDR2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:RIPK1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:SMAD3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:BAX"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CASP3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CYBB"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:FAS"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:GZMH"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:GZMK"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:HDAC1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:HPGDS"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:APO", "target": "P:MKI67"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:NCF2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:PIEZO1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:S100A8"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:SOD1"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:ATG5"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:APO", "target": "P:ATG7"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:APO", "target": "P:CDKN1A"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:CDKN2A"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:APO", "target": "P:HCAR2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:MMP9"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:APO", "target": "P:MSR1"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:APO", "target": "P:SQSTM1"}, {"type": "in_pathway", "source": "P:IFNG", "target": "PW:JAK-STAT"}, {"type": "maps_to_axis", "effect": "+", "source": "P:IFNG", "target": "AX:INF"}, {"type": "targeted_by", "source": "P:IFNG", "target": "R:IFN-gamma pathway blocked indirectly by JAK inhibitors"}, {"type": "targeted_by", "source": "P:IFNG", "target": "R:anti-IFNγ"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:STAT3"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:IL15"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:JAK1"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:JAK2"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:JAK3"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:STAT1"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:CXCL10"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:IL7R"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:SOCS3"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:STAT5A"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:TBX21"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:TYK2"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:IL6"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:TEC"}, {"type": "in_pathway", "source": "PW:JAK-STAT", "target": "P:STAT5B"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:STAT3"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:FOXP3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL15"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:JAK1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:JAK2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:JAK3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:STAT1"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:CTLA4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCL10"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCL12"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCR3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCR4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL7R"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:NLRP3"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:SOCS3"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:STAT5A"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TBX21"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TYK2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CCL26"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCL9"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL6"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:NFKBIZ"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:INF", "target": "P:POSTN"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TEC"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:XCL1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:XCL2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:BCL2L11"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:CALCA"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CASP1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CLEC16A"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:CXCL11"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:GSDMD"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:GZMA"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:HLA-B"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IFNGR1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL15RA"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:INF", "target": "P:IL2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL21"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:IL2RB"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL2RG"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:INF", "target": "P:IL7"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:IL9"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:LRRC32"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:OSM"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:SH2B3"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:INF", "target": "P:SOCS1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:STAT5B"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TLR2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TREM2"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:TSLP"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:INF", "target": "P:ULBP3"}, {"type": "targeted_by", "source": "P:TP53", "target": "R:ALRN-6924 (stapled peptide, clinical)"}, {"type": "targeted_by", "source": "P:TP53", "target": "R:Cyclophosphamide (inducer, not therapeutic)"}, {"type": "targeted_by", "source": "P:TP53", "target": "R:Pifithrin-alpha (experimental)"}, {"type": "targeted_by", "source": "P:TP53", "target": "R:Pifithrin-alpha (p53 inhibitor, experimental)"}, {"type": "targeted_by", "source": "P:TP53", "target": "R:p53 inhibitor(temporary)"}, {"type": "in_pathway", "source": "P:AKT1", "target": "PW:PI3K-AKT-mTOR"}, {"type": "targeted_by", "source": "P:AKT1", "target": "R:minoxidil (activates AKT)"}, {"type": "in_pathway", "source": "PW:PI3K-AKT-mTOR", "target": "P:SIRT1"}, {"type": "in_pathway", "source": "PW:PI3K-AKT-mTOR", "target": "P:MTOR"}, {"type": "in_pathway", "source": "PW:PI3K-AKT-mTOR", "target": "P:PTEN"}, {"type": "in_pathway", "source": "P:CD34", "target": "PW:HFSC niche"}, {"type": "maps_to_axis", "effect": "+", "source": "P:CD34", "target": "AX:HFSC"}, {"type": "in_pathway", "source": "PW:HFSC niche", "target": "P:SOX9"}, {"type": "in_pathway", "source": "PW:HFSC niche", "target": "P:LGR5"}, {"type": "in_pathway", "source": "PW:HFSC niche", "target": "P:MYLK"}, {"type": "in_pathway", "source": "PW:HFSC niche", "target": "P:PIEZO1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:SOX9"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:VDR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:BRD4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:DNMT1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:HR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:LGR5"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:PPARG"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:ESR1"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:HFSC", "target": "P:PRLR"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:AXL"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:CD44"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:COL17A1"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:HFSC", "target": "P:KRT15"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:MPC1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:HFSC", "target": "P:SPP1"}, {"type": "targeted_by", "source": "P:DKK1", "target": "R:anti-DKK1"}, {"type": "targeted_by", "source": "P:DKK1", "target": "R:anti-DKK1 / DKK1 inhibitors (investigational)"}, {"type": "targeted_by", "source": "P:DKK1", "target": "R:anti-DKK1 antibodies (preclinical)"}, {"type": "in_pathway", "source": "P:FOXP3", "target": "PW:Immune tolerance"}, {"type": "targeted_by", "source": "P:FOXP3", "target": "R:IL-2/Treg"}, {"type": "targeted_by", "source": "P:FOXP3", "target": "R:low-dose IL-2 (Treg-restoring, investigational)"}, {"type": "in_pathway", "source": "PW:Immune tolerance", "target": "P:CTLA4"}, {"type": "targeted_by", "source": "P:IL15", "target": "R:anti-IL-15 / anti-IL-15Rbeta (investigational)"}, {"type": "targeted_by", "source": "P:IL15", "target": "R:anti-IL-15Rbeta antibodies (preclinical/early clinical)"}, {"type": "targeted_by", "source": "P:IL15", "target": "R:anti-IL15"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:INCB054707"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:abrocitinib"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:baricitinib"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:ruxolitinib"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:tofacitinib"}, {"type": "targeted_by", "source": "P:JAK1", "target": "R:upadacitinib"}, {"type": "targeted_by", "source": "R:baricitinib", "target": "P:JAK2"}, {"type": "targeted_by", "source": "R:ruxolitinib", "target": "P:JAK2"}, {"type": "targeted_by", "source": "R:tofacitinib", "target": "P:JAK2"}, {"type": "targeted_by", "source": "R:tofacitinib", "target": "P:JAK3"}, {"type": "targeted_by", "source": "P:JAK3", "target": "R:ritlecitinib"}, {"type": "in_pathway", "source": "P:SHH", "target": "PW:Hedgehog"}, {"type": "maps_to_axis", "effect": "+", "source": "P:SHH", "target": "AX:SHH"}, {"type": "targeted_by", "source": "P:SHH", "target": "R:SAG / hedgehog agonists (experimental)"}, {"type": "targeted_by", "source": "P:SHH", "target": "R:SAG agonist"}, {"type": "targeted_by", "source": "P:SHH", "target": "R:Vismodegib (antagonist; opposing context)"}, {"type": "in_pathway", "source": "PW:Hedgehog", "target": "P:GLI1"}, {"type": "in_pathway", "source": "PW:Hedgehog", "target": "P:PTCH1"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:SHH", "target": "P:GLI1"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:SHH", "target": "P:PTCH1"}, {"type": "targeted_by", "source": "P:CYP19A1", "target": "R:aromatase inhibitors (anastrozole; promote hair loss by blocking this protective route)"}, {"type": "associated_with", "source": "P:EGFR", "target": "D:Scarring"}, {"type": "targeted_by", "source": "P:EGFR", "target": "R:Cetuximab"}, {"type": "targeted_by", "source": "P:EGFR", "target": "R:EGFR inhibitor(유발)"}, {"type": "targeted_by", "source": "P:EGFR", "target": "R:Erlotinib"}, {"type": "targeted_by", "source": "P:EGFR", "target": "R:Gefitinib (inhibitors that perturb hair)"}, {"type": "associated_with", "source": "D:Scarring", "target": "P:PPARG"}, {"type": "associated_with", "source": "D:Scarring", "target": "P:TAC1"}, {"type": "in_pathway", "source": "P:GPX4", "target": "PW:Oxidative stress"}, {"type": "targeted_by", "source": "P:GPX4", "target": "R:Ferrostatin-1 (tool)"}, {"type": "targeted_by", "source": "P:GPX4", "target": "R:Liproxstatin-1 (tool)"}, {"type": "targeted_by", "source": "P:GPX4", "target": "R:ferroptosis inhibitors / selenium (investigational)"}, {"type": "targeted_by", "source": "P:GPX4", "target": "R:ferrostatin"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:HMOX1"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:NOX4"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:CYBB"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:NCF2"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:S100A8"}, {"type": "in_pathway", "source": "PW:Oxidative stress", "target": "P:SOD1"}, {"type": "targeted_by", "source": "P:IGF1", "target": "R:IGF-1 / growth-factor-based regenerative therapies (investigational)"}, {"type": "targeted_by", "source": "P:IGF1", "target": "R:self-assembling IGF peptide"}, {"type": "in_pathway", "source": "P:PTGDS", "target": "PW:Prostaglandin"}, {"type": "targeted_by", "source": "P:PTGDS", "target": "R:PGD2 pathway inhibitor"}, {"type": "targeted_by", "source": "P:PTGDS", "target": "R:PTGDR2/CRTH2 antagonists targeting this axis (investigational)"}, {"type": "in_pathway", "source": "PW:Prostaglandin", "target": "P:PTGFR"}, {"type": "in_pathway", "source": "PW:Prostaglandin", "target": "P:PTGDR2"}, {"type": "in_pathway", "source": "PW:Prostaglandin", "target": "P:HPGDS"}, {"type": "targeted_by", "source": "P:PTGFR", "target": "R:bimatoprost"}, {"type": "targeted_by", "source": "P:PTGFR", "target": "R:latanoprost"}, {"type": "targeted_by", "source": "P:SFRP1", "target": "R:WAY-316606 (SFRP1 inhibitor, investigational)"}, {"type": "targeted_by", "source": "P:SFRP1", "target": "R:WAY-316606 (SFRP1 inhibitor, preclinical)"}, {"type": "targeted_by", "source": "P:SFRP1", "target": "R:WAY-316606(inhibitor)"}, {"type": "targeted_by", "source": "P:SFRP1", "target": "R:mRNA epigenomic SFRP1 suppressor (Omega Therapeutics, preclinical)"}, {"type": "in_pathway", "source": "P:TGFB1", "target": "PW:BMP/TGFβ"}, {"type": "targeted_by", "source": "P:TGFB1", "target": "R:Fresolimumab (anti-TGF-beta, experimental)"}, {"type": "targeted_by", "source": "P:TGFB1", "target": "R:TGF-beta inhibitors (investigational)"}, {"type": "targeted_by", "source": "P:TGFB1", "target": "R:TGFβ inhibitor"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:BMP2"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:BMP4"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:MSX2"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:NOG"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:SMAD3"}, {"type": "in_pathway", "source": "PW:BMP/TGFβ", "target": "P:POSTN"}, {"type": "targeted_by", "source": "P:FGF7", "target": "R:FGF7 / growth-factor regenerative therapies (investigational)"}, {"type": "targeted_by", "source": "P:FGF7", "target": "R:Palifermin (recombinant KGF)"}, {"type": "targeted_by", "source": "P:SIRT1", "target": "R:Jiawei Erzhiwan"}, {"type": "targeted_by", "source": "P:SIRT1", "target": "R:resveratrol (SIRT1 activator, investigational)"}, {"type": "in_pathway", "source": "P:VDR", "target": "PW:Nuclear receptor"}, {"type": "associated_with", "source": "P:VDR", "target": "D:Other"}, {"type": "targeted_by", "source": "P:VDR", "target": "R:Calcitriol / vitamin D analogs (adjunctive)"}, {"type": "targeted_by", "source": "P:VDR", "target": "R:VDR gene therapy"}, {"type": "targeted_by", "source": "P:VDR", "target": "R:calcitriol analog"}, {"type": "in_pathway", "source": "PW:Nuclear receptor", "target": "P:HR"}, {"type": "in_pathway", "source": "PW:Nuclear receptor", "target": "P:PPARG"}, {"type": "in_pathway", "source": "PW:Nuclear receptor", "target": "P:ESR1"}, {"type": "in_pathway", "source": "PW:Nuclear receptor", "target": "P:PRLR"}, {"type": "associated_with", "source": "D:Other", "target": "P:CRH"}, {"type": "associated_with", "source": "D:Other", "target": "P:FGF5"}, {"type": "associated_with", "source": "D:Other", "target": "P:HR"}, {"type": "associated_with", "source": "D:Other", "target": "P:KRT17"}, {"type": "associated_with", "source": "D:Other", "target": "P:MSX2"}, {"type": "associated_with", "source": "D:Other", "target": "P:PTCH1"}, {"type": "associated_with", "source": "D:Other", "target": "P:IL23A"}, {"type": "maps_to_axis", "effect": "+", "source": "P:BMP2", "target": "AX:BMP"}, {"type": "targeted_by", "source": "P:BMP2", "target": "R:BMP antagonists (investigational)"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:BMP", "target": "P:BMP4"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:BMP", "target": "P:FGF5"}, {"type": "maps_to_axis", "effect": "+", "source": "AX:BMP", "target": "P:MSX2"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:BMP", "target": "P:NOG"}, {"type": "maps_to_axis", "effect": "?", "source": "AX:BMP", "target": "P:NFATC1"}, {"type": "maps_to_axis", "effect": "-", "source": "AX:BMP", "target": "P:SCUBE3"}, {"type": "targeted_by", "source": "R:BMP antagonists (investigational)", "target": "P:BMP4"}, {"type": "targeted_by", "source": "P:BMP4", "target": "R:noggin(antagonist)"}, {"type": "in_pathway", "source": "P:BRD4", "target": "PW:Epigenetic"}, {"type": "targeted_by", "source": "P:BRD4", "target": "R:BET inhibitor"}, {"type": "targeted_by", "source": "P:BRD4", "target": "R:Birabresib"}, {"type": "targeted_by", "source": "P:BRD4", "target": "R:JQ1 (tool)"}, {"type": "targeted_by", "source": "P:BRD4", "target": "R:Molibresib"}, {"type": "in_pathway", "source": "PW:Epigenetic", "target": "P:DNMT1"}, {"type": "targeted_by", "source": "P:CDK4", "target": "R:Abemaciclib"}, {"type": "targeted_by", "source": "P:CDK4", "target": "R:Palbociclib"}, {"type": "targeted_by", "source": "P:CDK4", "target": "R:Ribociclib"}, {"type": "targeted_by", "source": "P:CDK4", "target": "R:palbociclib(CDK4/6i)"}, {"type": "targeted_by", "source": "R:Abemaciclib", "target": "P:CDK6"}, {"type": "targeted_by", "source": "R:Palbociclib", "target": "P:CDK6"}, {"type": "targeted_by", "source": "R:Ribociclib", "target": "P:CDK6"}, {"type": "targeted_by", "source": "P:CDK6", "target": "R:palbociclib"}, {"type": "targeted_by", "source": "P:CDK6", "target": "R:ribociclib"}, {"type": "targeted_by", "source": "P:CDK6", "target": "R:trilaciclib (concept for CIA)"}, {"type": "in_pathway", "source": "P:CRH", "target": "PW:Stress/HPA"}, {"type": "targeted_by", "source": "P:CRH", "target": "R:Antalarmin (CRHR1 antagonist, experimental)"}, {"type": "targeted_by", "source": "P:CRH", "target": "R:astressin-B(antagonist)"}, {"type": "targeted_by", "source": "P:CTLA4", "target": "R:abatacept"}, {"type": "targeted_by", "source": "P:CTLA4", "target": "R:abatacept (CTLA4-Ig, investigational in AA)"}, {"type": "in_pathway", "source": "P:CXCL12", "target": "PW:Chemokine"}, {"type": "targeted_by", "source": "P:CXCL12", "target": "R:AMD3100"}, {"type": "targeted_by", "source": "P:CXCL12", "target": "R:Plerixafor (CXCR4 antagonist)"}, {"type": "targeted_by", "source": "P:CXCL12", "target": "R:anti-CXCL12"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:CXCR3"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:CXCR4"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:CCL26"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:CXCL9"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:XCL1"}, {"type": "in_pathway", "source": "PW:Chemokine", "target": "P:XCL2"}, {"type": "targeted_by", "source": "P:CXCR3", "target": "R:CXCR3 antagonist"}, {"type": "targeted_by", "source": "P:CXCR3", "target": "R:CXCR3 antagonists (preclinical)"}, {"type": "targeted_by", "source": "P:CXCR4", "target": "R:AMD3100(plerixafor)"}, {"type": "targeted_by", "source": "P:CXCR4", "target": "R:plerixafor (CXCR4 antagonist, not AA-specific)"}, {"type": "targeted_by", "source": "P:DNMT1", "target": "R:Azacitidine"}, {"type": "targeted_by", "source": "P:DNMT1", "target": "R:Decitabine"}, {"type": "targeted_by", "source": "P:FGF5", "target": "R:Anti-FGF5 cosmetics (unproven)"}, {"type": "targeted_by", "source": "P:FGF5", "target": "R:FGF5 inhibitor"}, {"type": "associated_with", "source": "P:GAS6", "target": "D:TelogenEffluvium"}, {"type": "targeted_by", "source": "P:GAS6", "target": "R:GAS6 gene therapy"}, {"type": "targeted_by", "source": "P:GAS6", "target": "R:recombinant GAS6 / AXL agonists (preclinical)"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:TAC1"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:AXL"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:CD44"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:CXXC5"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:OSM"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:SPP1"}, {"type": "associated_with", "source": "D:TelogenEffluvium", "target": "P:TREM2"}, {"type": "targeted_by", "source": "P:GLI1", "target": "R:Glasdegib"}, {"type": "targeted_by", "source": "P:GLI1", "target": "R:Sonidegib"}, {"type": "targeted_by", "source": "P:GLI1", "target": "R:Vismodegib"}, {"type": "targeted_by", "source": "P:HGF", "target": "R:HGF-based regenerative approaches (investigational)"}, {"type": "targeted_by", "source": "P:HMOX1", "target": "R:sulforaphane(Nrf2)"}, {"type": "targeted_by", "source": "P:IL7R", "target": "R:anti-IL7R"}, {"type": "in_pathway", "source": "P:KRT17", "target": "PW:Structural keratin"}, {"type": "in_pathway", "source": "P:LAMA5", "target": "PW:ECM/adhesion"}, {"type": "targeted_by", "source": "P:LAMA5", "target": "R:Laminin-511-E8 fragment (experimental)"}, {"type": "targeted_by", "source": "P:MTOR", "target": "R:rapamycin (mTOR inhibitor; context-dependent effects on follicle)"}, {"type": "in_pathway", "source": "P:NLRP3", "target": "PW:Inflammasome"}, {"type": "targeted_by", "source": "P:NLRP3", "target": "R:MCC950"}, {"type": "targeted_by", "source": "P:NLRP3", "target": "R:NLRP3 inhibitors (preclinical)"}, {"type": "targeted_by", "source": "P:NLRP3", "target": "R:total glucosides of paeony"}, {"type": "in_pathway", "source": "PW:Inflammasome", "target": "P:NFKBIZ"}, {"type": "targeted_by", "source": "P:NOG", "target": "R:recombinant noggin (investigational)"}, {"type": "targeted_by", "source": "P:NOX4", "target": "R:ACA(NADPH oxidase 조절)"}, {"type": "targeted_by", "source": "P:NOX4", "target": "R:NOX4 inhibitors / antioxidants (investigational)"}, {"type": "targeted_by", "source": "P:PDGFA", "target": "R:PRP"}, {"type": "targeted_by", "source": "P:PDGFA", "target": "R:platelet-rich plasma (delivers PDGF)"}, {"type": "targeted_by", "source": "P:PPARG", "target": "R:PPARγ agonist"}, {"type": "targeted_by", "source": "P:PPARG", "target": "R:pioglitazone"}, {"type": "targeted_by", "source": "P:PPARG", "target": "R:topical PPAR-gamma agonists (investigational)"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:fevipiprant"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:fevipiprant (repurposing)"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:ramatroban"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:setipiprant"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:setipiprant (CRTH2 antagonist, trialed for AGA)"}, {"type": "targeted_by", "source": "P:PTGDR2", "target": "R:setipiprant (Phase 2)"}, {"type": "targeted_by", "source": "R:fevipiprant", "target": "P:HCAR2"}, {"type": "targeted_by", "source": "R:ramatroban", "target": "P:HCAR2"}, {"type": "in_pathway", "source": "P:RIPK1", "target": "PW:Necroptosis"}, {"type": "targeted_by", "source": "P:RIPK1", "target": "R:RIPK1 inhibitor"}, {"type": "targeted_by", "source": "P:RIPK1", "target": "R:RIPK1 inhibitors (investigational)"}, {"type": "targeted_by", "source": "P:SMAD3", "target": "R:SIS3 (SMAD3 inhibitor, experimental)"}, {"type": "targeted_by", "source": "P:SOCS3", "target": "R:SOCS3 mimetic"}, {"type": "targeted_by", "source": "P:SRD5A1", "target": "R:finasteride (weak)"}, {"type": "targeted_by", "source": "P:SRD5A3", "target": "R:dutasteride (partial)"}, {"type": "targeted_by", "source": "P:TBX21", "target": "R:T-bet siRNA"}, {"type": "targeted_by", "source": "P:TYK2", "target": "R:deucravacitinib"}, {"type": "targeted_by", "source": "P:TYK2", "target": "R:ritlecitinib (PLCG2/JAK3 dual)"}, {"type": "targeted_by", "source": "P:WNT10B", "target": "R:Wnt mimetics (investigational)"}, {"type": "targeted_by", "source": "P:WNT3A", "target": "R:WNT agonists / GSK3 inhibitors (experimental)"}, {"type": "targeted_by", "source": "P:WNT3A", "target": "R:recombinant WNT3A / Wnt mimetics (investigational)"}, {"type": "in_pathway", "source": "P:ABCB1", "target": "PW:Other"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:ADM"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:COL5A3"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:COL6A6"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:CRP"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:DCT"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:ENTPD1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:HLA-DQB1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:HRH1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IGHE"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL10"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL13"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL13RA1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL1B"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL23A"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:IL4R"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:KL"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:KLRK1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:KRT81"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:LAMC1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:LAMC3"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:MAPK1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:MAPK8"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:MICA"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:MICB"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:NT5E"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:PAM"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:PPARGC1A"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:SQLE"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:SREBF1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TAC1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TNF"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TNFRSF4"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TYR"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TYRP1"}, {"type": "targeted_by", "source": "P:CASP3", "target": "R:Emricasan (pan-caspase inhibitor, experimental)"}, {"type": "targeted_by", "source": "P:KLRK1", "target": "R:anti-NKG2D (investigational)"}, {"type": "targeted_by", "source": "P:KLRK1", "target": "R:anti-NKG2D antibodies (investigational)"}, {"type": "targeted_by", "source": "P:PPARGC1A", "target": "R:Bezafibrate"}, {"type": "targeted_by", "source": "P:PPARGC1A", "target": "R:Metformin (indirect)"}, {"type": "targeted_by", "source": "P:TAC1", "target": "R:aprepitant / NK1R antagonists (concept)"}, {"type": "targeted_by", "source": "P:TNFRSF4", "target": "R:amlitelimab (anti-OX40L, repurposing concept)"}, {"type": "targeted_by", "source": "P:TNFRSF4", "target": "R:anti-OX40 antibodies (InmaGene, investigational)"}, {"type": "in_pathway", "source": "P:ATF4", "target": "PW:integrated stress response effector"}, {"type": "in_pathway", "source": "P:ATG5", "target": "PW:Macroautophagy"}, {"type": "in_pathway", "source": "PW:Macroautophagy", "target": "P:ATG7"}, {"type": "in_pathway", "source": "P:AXL", "target": "PW:GAS6-AXL/TAM receptor (HFSC activation)"}, {"type": "targeted_by", "source": "P:AXL", "target": "R:AXL agonists (preclinical)"}, {"type": "in_pathway", "source": "P:BCL2L11", "target": "PW:intrinsic apoptosis / immune tolerance"}, {"type": "in_pathway", "source": "P:CALCA", "target": "PW:Sensory neuropeptide restoration of immune privilege"}, {"type": "targeted_by", "source": "P:CALCA", "target": "R:CGRP analogs / capsaicin-induced CGRP release (concept)"}, {"type": "in_pathway", "source": "P:CASP1", "target": "PW:Inflammasome/pyroptosis"}, {"type": "in_pathway", "source": "PW:Inflammasome/pyroptosis", "target": "P:GSDMD"}, {"type": "in_pathway", "source": "P:CD44", "target": "PW:Osteopontin (OPN)-CD44 (HFSC hyperactivation)"}, {"type": "targeted_by", "source": "P:CD44", "target": "R:CD44 agonist peptides (preclinical)"}, {"type": "in_pathway", "source": "PW:Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "target": "P:SPP1"}, {"type": "in_pathway", "source": "P:CD8A", "target": "PW:Cytotoxic immunity"}, {"type": "in_pathway", "source": "PW:Cytotoxic immunity", "target": "P:GZMB"}, {"type": "in_pathway", "source": "P:CDKN1A", "target": "PW:Cell-cycle/apoptosis (p53)"}, {"type": "in_pathway", "source": "P:CDKN2A", "target": "PW:p16-Rb senescence"}, {"type": "targeted_by", "source": "P:CDKN2A", "target": "R:Navitoclax"}, {"type": "targeted_by", "source": "P:CDKN2A", "target": "R:Senolytics (Dasatinib+Quercetin)"}, {"type": "in_pathway", "source": "P:CLEC16A", "target": "PW:autophagy / immune regulation (KIAA0350 locus)"}, {"type": "in_pathway", "source": "P:COL17A1", "target": "PW:hemidesmosome basement-membrane anchorage / HFSC maintenance"}, {"type": "in_pathway", "source": "P:CXCL11", "target": "PW:CXCR3 chemokine axis"}, {"type": "in_pathway", "source": "P:CXXC5", "target": "PW:WNT/beta-catenin (negative feedback via Dishevelled)"}, {"type": "targeted_by", "source": "P:CXXC5", "target": "R:PTD-DBM (peptide, preclinical/early clinical)"}, {"type": "in_pathway", "source": "P:CYP1B1", "target": "PW:xenobiotic/estrogen metabolism (2p22 locus)"}, {"type": "in_pathway", "source": "P:DLX3", "target": "PW:Transcription factor"}, {"type": "in_pathway", "source": "PW:Transcription factor", "target": "P:FOXN1"}, {"type": "in_pathway", "source": "P:EIF2AK4", "target": "PW:integrated stress response (eIF2alpha-ATF4)"}, {"type": "in_pathway", "source": "P:EZH2", "target": "PW:PRC2 / H3K27me3 repression"}, {"type": "targeted_by", "source": "P:EZH2", "target": "R:GSK126 (tool)"}, {"type": "targeted_by", "source": "P:EZH2", "target": "R:Tazemetostat"}, {"type": "in_pathway", "source": "P:F11R", "target": "PW:Tight-junction adhesion / barrier"}, {"type": "in_pathway", "source": "P:F2R", "target": "PW:protease-activated receptor signaling in dermal papilla"}, {"type": "targeted_by", "source": "P:GSDMD", "target": "R:disulfiram (GSDMD inhibitor, investigational)"}, {"type": "in_pathway", "source": "P:GZMA", "target": "PW:cytotoxic T-cell - dermal papilla crosstalk (GZMA-F2R)"}, {"type": "in_pathway", "source": "P:HCAR2", "target": "PW:PGD2-GPR44(CRTH2/PTGDR2) inhibition of hair growth"}, {"type": "targeted_by", "source": "P:HCAR2", "target": "R:setipiprant (Phase 2, AGA)"}, {"type": "in_pathway", "source": "P:HLA-B", "target": "PW:MHC class I antigen presentation (6p21 locus)"}, {"type": "in_pathway", "source": "P:IFNGR1", "target": "PW:Type II interferon"}, {"type": "in_pathway", "source": "P:IKZF4", "target": "PW:FOXP3 transcriptional program / Treg stability"}, {"type": "in_pathway", "source": "P:IL15RA", "target": "PW:Cytokine (common gamma chain)"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL2"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL2RG"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL7"}, {"type": "targeted_by", "source": "P:IL2", "target": "R:low-dose IL-2 / aldesleukin (investigational)"}, {"type": "in_pathway", "source": "P:IL21", "target": "PW:Tfh/Th17 cytokine signaling (IL2/IL21 locus)"}, {"type": "in_pathway", "source": "P:IL2RB", "target": "PW:Low-dose/PEG-IL-2 -> Treg expansion (tolerance restoration)"}, {"type": "targeted_by", "source": "P:IL2RB", "target": "R:rezpegaldesleukin (Nektar NKTR-358, Phase 2, Fast Track)"}, {"type": "targeted_by", "source": "P:IL2RG", "target": "R:ritlecitinib (via JAK3)"}, {"type": "in_pathway", "source": "P:IL9", "target": "PW:Th9 / mast-cell cytokine signaling (gamma-chain)"}, {"type": "in_pathway", "source": "P:KRT15", "target": "PW:Bulge HFSC intermediate-filament marker"}, {"type": "in_pathway", "source": "P:KRT75", "target": "PW:Keratin/structural"}, {"type": "in_pathway", "source": "P:LDHA", "target": "PW:Glycolytic lactate metabolism"}, {"type": "targeted_by", "source": "P:LDHA", "target": "R:FX11 (experimental)"}, {"type": "targeted_by", "source": "P:LDHA", "target": "R:Oxamate (experimental)"}, {"type": "in_pathway", "source": "P:LGR6", "target": "PW:WNT/R-spondin potentiation"}, {"type": "in_pathway", "source": "P:LRP5", "target": "PW:Wnt/beta-catenin"}, {"type": "in_pathway", "source": "P:LRRC32", "target": "PW:TGF-beta latency / regulatory T-cell function"}, {"type": "in_pathway", "source": "P:MMP9", "target": "PW:extracellular matrix remodeling / fibrosis"}, {"type": "in_pathway", "source": "P:MPC1", "target": "PW:mitochondrial pyruvate import / glycolytic HFSC activation"}, {"type": "in_pathway", "source": "P:MSR1", "target": "PW:M2 macrophage-mediated fibrosis / lipid scavenging"}, {"type": "associated_with", "source": "P:MSR1", "target": "D:lichen planopilaris / CCCA"}, {"type": "in_pathway", "source": "P:NFATC1", "target": "PW:BMP-NFATc1 quiescence control"}, {"type": "targeted_by", "source": "P:NFATC1", "target": "R:Cyclosporine A"}, {"type": "targeted_by", "source": "P:NFATC1", "target": "R:Tacrolimus"}, {"type": "in_pathway", "source": "P:OSM", "target": "PW:OSM/OSMR -> JAK2-STAT5 (HFSC quiescence)"}, {"type": "targeted_by", "source": "P:OSM", "target": "R:OSM/OSMR-targeting antibodies (in development for other indications)"}, {"type": "in_pathway", "source": "P:PADI3", "target": "PW:hair-shaft protein citrullination / inner root sheath integrity"}, {"type": "in_pathway", "source": "P:PTH1R", "target": "PW:GPCR (PTH/PTHrP)"}, {"type": "targeted_by", "source": "P:PTH1R", "target": "R:Abaloparatide / Teriparatide (PTH1R agonists)"}, {"type": "targeted_by", "source": "P:PTH1R", "target": "R:PTH-CBD (collagen-binding PTH agonist)"}, {"type": "in_pathway", "source": "P:S100A3", "target": "PW:PADI3 substrate / cuticle calcium signaling"}, {"type": "in_pathway", "source": "P:SCUBE3", "target": "PW:TGF-beta/SHH activation (dermal papilla anagen signal)"}, {"type": "targeted_by", "source": "P:SCUBE3", "target": "R:AMP-126"}, {"type": "targeted_by", "source": "P:SCUBE3", "target": "R:AMP-303 (Amplifica, Phase 1/2)"}, {"type": "in_pathway", "source": "P:SFRP4", "target": "PW:Wnt antagonism / fibrosis"}, {"type": "in_pathway", "source": "P:SH2B3", "target": "PW:JAK-STAT negative regulation / cytokine signaling"}, {"type": "in_pathway", "source": "P:SOCS1", "target": "PW:JAK-STAT negative feedback"}, {"type": "targeted_by", "source": "P:SPP1", "target": "R:recombinant osteopontin / OPN peptides (preclinical)"}, {"type": "in_pathway", "source": "P:SQSTM1", "target": "PW:Selective autophagy / KEAP1-NRF2 stress"}, {"type": "in_pathway", "source": "P:TCF3", "target": "PW:WNT/TCF stemness repression"}, {"type": "in_pathway", "source": "P:TCF7", "target": "PW:WNT/beta-catenin effector"}, {"type": "in_pathway", "source": "P:TCHH", "target": "PW:PADI3 substrate / inner root sheath cornification"}, {"type": "in_pathway", "source": "P:TLR2", "target": "PW:innate immune sensing of microbiome lipids / NLRP3 priming"}, {"type": "in_pathway", "source": "P:TREM2", "target": "PW:TREM2+ macrophage / Oncostatin M -> JAK-STAT5 (HFSC quiescence)"}, {"type": "targeted_by", "source": "P:TREM2", "target": "R:anti-OSM / OSMR blockade (conceptual)"}, {"type": "in_pathway", "source": "P:TRPS1", "target": "PW:Wnt regulation downstream of YAP inhibition"}, {"type": "in_pathway", "source": "P:TSLP", "target": "PW:epithelial alarmin / IL-7R-TSLPR signaling"}, {"type": "in_pathway", "source": "P:ULBP3", "target": "PW:NKG2D innate cytotoxicity / immune-privilege collapse"}, {"type": "in_pathway", "source": "P:VCAN", "target": "PW:Dermal-papilla ECM / inductivity"}, {"type": "in_pathway", "source": "P:YAP1", "target": "PW:Hippo / mechanotransduction in connective tissue sheath"}, {"type": "in_pathway", "source": "P:ZEB1", "target": "PW:EMT / fibrotic remodeling"}]} |