333 lines
7.0 KiB
JSON
333 lines
7.0 KiB
JSON
{
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"_description": "치료 타이밍 모델의 계층적 베이즈 UQ: class별 모집단 (lag,tau) 사후분포, 시험 간 분산, 식별성, 사후예측 밴드, LOTO 커버리지(mean-only vs population).",
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"model": "y_ij ~ N(A_i·(1-exp(-(t-lag_i)/tau_i)), sigma); lag_i~N(mu_lag,sd_lag), tau_i~N(mu_tau,sd_tau).",
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"classes": {
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"JAK_inhibitor": {
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"class": "JAK_inhibitor",
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"n_trajectories": 5,
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"trajectory_ids": [
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"deuruxolitinib_THRIVE-AA1_12mg",
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"deuruxolitinib_THRIVE-AA1_8mg",
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"deuruxolitinib_THRIVE-AA2_12mg",
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"brepocitinib_NCT02974868",
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"ritlecitinib_NCT02974868"
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],
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"lag_mean": 0.742,
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"lag_sd": 0.075,
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"lag_hdi90": [
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0.635,
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0.837
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],
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"between_trial_lag_sd": 0.112,
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"tau_mean": 2.99,
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"tau_sd": 0.949,
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"tau_hdi90": [
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1.492,
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4.483
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],
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"between_trial_tau_sd": 1.958,
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"sigma_mean": 0.027,
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"mulag_mutau_corr": -0.076,
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"prior_lag": 1.5,
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"prior_tau": 4.0,
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"post_band": {
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"months": [
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0,
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0.5,
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1,
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1.5,
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2,
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3,
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4,
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6,
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9,
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12,
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18,
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24
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],
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"median": [
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0.0,
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0.0,
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0.0831,
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0.2248,
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0.3458,
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0.5334,
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0.6666,
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0.8297,
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0.938,
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0.9774,
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0.997,
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0.9996
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],
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"lo": [
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-0.045,
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-0.0438,
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-0.0003,
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0.0853,
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0.157,
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0.2777,
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0.3782,
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0.5452,
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0.7065,
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0.8091,
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0.9117,
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0.9408
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],
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"hi": [
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0.045,
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0.0508,
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0.9136,
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0.9935,
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0.9974,
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1.0046,
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1.0096,
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1.0166,
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1.0251,
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1.0321,
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1.0387,
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1.0418
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]
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},
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"loto_coverage": {
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"nominal": 0.9,
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"mean_only_empirical": 0.531,
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"population_empirical": 1.0,
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"n_points": 32,
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"by_trajectory": [
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{
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"held": "deuruxolitinib_THRIVE-AA1_12mg",
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"n": 6,
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"mean_in": 5,
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"pop_in": 6
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},
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{
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"held": "deuruxolitinib_THRIVE-AA1_8mg",
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"n": 6,
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"mean_in": 5,
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"pop_in": 6
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},
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{
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"held": "deuruxolitinib_THRIVE-AA2_12mg",
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"n": 6,
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"mean_in": 5,
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"pop_in": 6
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},
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{
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"held": "brepocitinib_NCT02974868",
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"n": 7,
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"mean_in": 1,
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"pop_in": 7
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},
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{
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"held": "ritlecitinib_NCT02974868",
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"n": 7,
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"mean_in": 1,
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"pop_in": 7
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}
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]
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}
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},
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"finasteride": {
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"class": "finasteride",
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"n_trajectories": 3,
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"trajectory_ids": [
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"finasteride_1mg_NCT01231607",
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"finasteride_1mg_Kaufman_2yr",
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"finasteride_oral_P3074_NCT03004469"
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],
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"lag_mean": 0.943,
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"lag_sd": 0.642,
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"lag_hdi90": [
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0.086,
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1.863
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],
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"between_trial_lag_sd": 0.514,
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"tau_mean": 2.99,
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"tau_sd": 2.237,
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"tau_hdi90": [
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0.109,
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6.064
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],
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"between_trial_tau_sd": 3.3,
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"sigma_mean": 0.046,
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"mulag_mutau_corr": -0.118,
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"prior_lag": 3.0,
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"prior_tau": 6.0,
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"post_band": {
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"months": [
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0,
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0.5,
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1,
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1.5,
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2,
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3,
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4,
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6,
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9,
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12,
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18,
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24
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],
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"median": [
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0.0,
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0.0,
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0.0618,
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0.2069,
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0.3287,
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0.5361,
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0.6798,
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0.8493,
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0.9533,
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0.9851,
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0.9985,
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0.9998
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],
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"lo": [
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-0.0838,
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-0.0717,
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-0.0517,
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-0.0311,
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-0.009,
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0.0843,
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0.198,
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0.3546,
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0.5146,
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0.6342,
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0.7739,
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0.8467
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],
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"hi": [
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0.085,
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0.7056,
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0.9896,
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1.012,
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1.0258,
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1.0432,
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1.0498,
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1.0602,
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1.0661,
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1.071,
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1.0768,
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1.0794
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]
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},
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"loto_coverage": {
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"nominal": 0.9,
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"mean_only_empirical": 0.778,
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"population_empirical": 0.889,
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"n_points": 9,
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"by_trajectory": [
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{
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"held": "finasteride_1mg_NCT01231607",
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"n": 3,
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"mean_in": 3,
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"pop_in": 3
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},
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{
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"held": "finasteride_1mg_Kaufman_2yr",
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"n": 3,
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"mean_in": 2,
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"pop_in": 2
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},
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{
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"held": "finasteride_oral_P3074_NCT03004469",
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"n": 3,
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"mean_in": 2,
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"pop_in": 3
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}
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]
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}
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},
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"dutasteride": {
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"class": "dutasteride",
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"n_trajectories": 2,
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"trajectory_ids": [
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"dutasteride_0.5mg_NCT01231607",
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"dutasteride_0.5mg_NCT00441116"
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],
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"lag_mean": 1.096,
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"lag_sd": 0.447,
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"lag_hdi90": [
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0.311,
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1.679
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],
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"between_trial_lag_sd": 0.585,
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"tau_mean": 2.289,
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"tau_sd": 1.524,
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"tau_hdi90": [
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0.1,
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4.196
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],
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"between_trial_tau_sd": 2.374,
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"sigma_mean": 0.0,
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"mulag_mutau_corr": -0.012,
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"prior_lag": 2.5,
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"prior_tau": 5.0,
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"post_band": {
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"months": [
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0,
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0.5,
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1,
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1.5,
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2,
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3,
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4,
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6,
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9,
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12,
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18,
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24
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],
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"median": [
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0.0,
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0.0,
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0.0,
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0.1809,
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0.356,
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0.6106,
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0.7653,
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0.9161,
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0.9818,
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0.9961,
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0.9998,
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1.0
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],
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"lo": [
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-0.0,
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-0.0,
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-0.0,
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-0.0,
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0.0,
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0.1394,
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0.2673,
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0.4566,
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0.6427,
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0.7483,
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0.895,
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0.9481
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],
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"hi": [
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0.0,
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0.284,
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0.9498,
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0.9995,
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1.0,
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1.0,
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1.0,
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1.0,
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1.0,
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1.0,
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1.0,
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1.0
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]
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},
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"loto_coverage": null
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}
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},
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"overall_coverage": {
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"nominal": 0.9,
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"mean_only_empirical": 0.585,
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"population_empirical": 0.976,
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"n_points": 41
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}
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} |