3229 lines
53 KiB
JSON
3229 lines
53 KiB
JSON
{
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|
"_description": "기전→단백질 네트워크→시간(개월) 변화. 노드=단백질, 엣지=활성/억제, 노드 활성=질환평형+회복·r(t)·(건강−질환). 치료별 표적 그룹이 달라 다른 단백질을 변화시킴.",
|
|
"nodes": [
|
|
{
|
|
"id": "AR",
|
|
"label": "AR",
|
|
"group": "androgen",
|
|
"x": 7,
|
|
"y": 22
|
|
},
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|
{
|
|
"id": "SRD5A2",
|
|
"label": "SRD5A2",
|
|
"group": "androgen",
|
|
"x": 7,
|
|
"y": 36
|
|
},
|
|
{
|
|
"id": "IFNG",
|
|
"label": "IFNG",
|
|
"group": "immune",
|
|
"x": 7,
|
|
"y": 62
|
|
},
|
|
{
|
|
"id": "CD8A",
|
|
"label": "CD8A",
|
|
"group": "immune",
|
|
"x": 7,
|
|
"y": 76
|
|
},
|
|
{
|
|
"id": "HLA-DQB1",
|
|
"label": "HLA-DQB1",
|
|
"group": "immune",
|
|
"x": 7,
|
|
"y": 90
|
|
},
|
|
{
|
|
"id": "CXCL10",
|
|
"label": "CXCL10",
|
|
"group": "immune",
|
|
"x": 22,
|
|
"y": 84
|
|
},
|
|
{
|
|
"id": "DKK1",
|
|
"label": "DKK1",
|
|
"group": "wnt_antag",
|
|
"x": 27,
|
|
"y": 26
|
|
},
|
|
{
|
|
"id": "SFRP1",
|
|
"label": "SFRP1",
|
|
"group": "wnt_antag",
|
|
"x": 27,
|
|
"y": 40
|
|
},
|
|
{
|
|
"id": "BMP4",
|
|
"label": "BMP4",
|
|
"group": "bmp",
|
|
"x": 30,
|
|
"y": 54
|
|
},
|
|
{
|
|
"id": "ID1",
|
|
"label": "ID1",
|
|
"group": "bmp",
|
|
"x": 42,
|
|
"y": 60
|
|
},
|
|
{
|
|
"id": "WNT10B",
|
|
"label": "WNT10B",
|
|
"group": "wnt",
|
|
"x": 46,
|
|
"y": 12
|
|
},
|
|
{
|
|
"id": "CTNNB1",
|
|
"label": "β-catenin",
|
|
"group": "wnt",
|
|
"x": 48,
|
|
"y": 24
|
|
},
|
|
{
|
|
"id": "LEF1",
|
|
"label": "LEF1",
|
|
"group": "wnt",
|
|
"x": 60,
|
|
"y": 30
|
|
},
|
|
{
|
|
"id": "AXIN2",
|
|
"label": "AXIN2",
|
|
"group": "wnt",
|
|
"x": 60,
|
|
"y": 16
|
|
},
|
|
{
|
|
"id": "SHH",
|
|
"label": "SHH",
|
|
"group": "shh",
|
|
"x": 50,
|
|
"y": 70
|
|
},
|
|
{
|
|
"id": "GLI1",
|
|
"label": "GLI1",
|
|
"group": "shh",
|
|
"x": 62,
|
|
"y": 66
|
|
},
|
|
{
|
|
"id": "SOX2",
|
|
"label": "SOX2",
|
|
"group": "dp",
|
|
"x": 70,
|
|
"y": 24
|
|
},
|
|
{
|
|
"id": "VCAN",
|
|
"label": "VCAN",
|
|
"group": "dp",
|
|
"x": 72,
|
|
"y": 38
|
|
},
|
|
{
|
|
"id": "ALPL",
|
|
"label": "ALPL",
|
|
"group": "dp",
|
|
"x": 70,
|
|
"y": 50
|
|
},
|
|
{
|
|
"id": "KRT15",
|
|
"label": "KRT15",
|
|
"group": "hfsc",
|
|
"x": 72,
|
|
"y": 64
|
|
},
|
|
{
|
|
"id": "CD34",
|
|
"label": "CD34",
|
|
"group": "hfsc",
|
|
"x": 72,
|
|
"y": 78
|
|
},
|
|
{
|
|
"id": "LGR5",
|
|
"label": "LGR5",
|
|
"group": "hfsc",
|
|
"x": 72,
|
|
"y": 90
|
|
},
|
|
{
|
|
"id": "KRT85",
|
|
"label": "KRT85",
|
|
"group": "hair",
|
|
"x": 92,
|
|
"y": 34
|
|
},
|
|
{
|
|
"id": "KRT35",
|
|
"label": "KRT35",
|
|
"group": "hair",
|
|
"x": 92,
|
|
"y": 50
|
|
}
|
|
],
|
|
"edges": [
|
|
{
|
|
"from": "AR",
|
|
"to": "DKK1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "SRD5A2",
|
|
"to": "AR",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "AR",
|
|
"to": "SFRP1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "DKK1",
|
|
"to": "CTNNB1",
|
|
"type": "inhibit"
|
|
},
|
|
{
|
|
"from": "SFRP1",
|
|
"to": "WNT10B",
|
|
"type": "inhibit"
|
|
},
|
|
{
|
|
"from": "WNT10B",
|
|
"to": "CTNNB1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CTNNB1",
|
|
"to": "LEF1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CTNNB1",
|
|
"to": "AXIN2",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "LEF1",
|
|
"to": "KRT85",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "LEF1",
|
|
"to": "KRT35",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "BMP4",
|
|
"to": "ID1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "ID1",
|
|
"to": "CTNNB1",
|
|
"type": "inhibit"
|
|
},
|
|
{
|
|
"from": "BMP4",
|
|
"to": "KRT35",
|
|
"type": "inhibit"
|
|
},
|
|
{
|
|
"from": "CTNNB1",
|
|
"to": "SHH",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "SHH",
|
|
"to": "GLI1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "GLI1",
|
|
"to": "SOX2",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CTNNB1",
|
|
"to": "SOX2",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "SOX2",
|
|
"to": "VCAN",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "VCAN",
|
|
"to": "ALPL",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "ALPL",
|
|
"to": "KRT35",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "SOX2",
|
|
"to": "LEF1",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CTNNB1",
|
|
"to": "KRT15",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "KRT15",
|
|
"to": "CD34",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CD34",
|
|
"to": "LGR5",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "LGR5",
|
|
"to": "KRT35",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "IFNG",
|
|
"to": "CXCL10",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "HLA-DQB1",
|
|
"to": "CD8A",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CD8A",
|
|
"to": "IFNG",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CXCL10",
|
|
"to": "CD8A",
|
|
"type": "activate"
|
|
},
|
|
{
|
|
"from": "CD8A",
|
|
"to": "KRT35",
|
|
"type": "inhibit"
|
|
},
|
|
{
|
|
"from": "IFNG",
|
|
"to": "LGR5",
|
|
"type": "inhibit"
|
|
}
|
|
],
|
|
"months": [
|
|
0,
|
|
0.25,
|
|
0.5,
|
|
1,
|
|
1.5,
|
|
2,
|
|
3,
|
|
4,
|
|
6,
|
|
9,
|
|
12,
|
|
18,
|
|
24,
|
|
36
|
|
],
|
|
"scenarios": {
|
|
"AGA|untreated": {
|
|
"label": "남성형 탈모 · 무치료",
|
|
"drug": "untreated",
|
|
"months": [
|
|
0,
|
|
0.25,
|
|
0.5,
|
|
1,
|
|
1.5,
|
|
2,
|
|
3,
|
|
4,
|
|
6,
|
|
9,
|
|
12,
|
|
18,
|
|
24,
|
|
36
|
|
],
|
|
"activity": {
|
|
"AR": [
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85
|
|
],
|
|
"SRD5A2": [
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85
|
|
],
|
|
"IFNG": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"CD8A": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"HLA-DQB1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"CXCL10": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"DKK1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"SFRP1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"BMP4": [
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
|
|
"ID1": [
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
|
|
"WNT10B": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
|
"CTNNB1": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
|
"LEF1": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
|
"AXIN2": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
|
"SHH": [
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
],
|
|
"GLI1": [
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
],
|
|
"SOX2": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35
|
|
],
|
|
"VCAN": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
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0.3,
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0.409,
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0.536,
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0.596,
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0.625,
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0.644,
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0.649,
|
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0.65
|
|
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|
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0.3,
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0.409,
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0.536,
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0.625,
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0.644,
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0.65
|
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0.688,
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0.842,
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0.848,
|
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0.85
|
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0.814,
|
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0.842,
|
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0.848,
|
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0.85
|
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0.842,
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0.566,
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0.702,
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0.731,
|
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0.751,
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0.756,
|
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0.757
|
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0.4,
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0.512,
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0.566,
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0.641,
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0.702,
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0.751,
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0.756,
|
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0.757
|
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|
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0.4,
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0.4,
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0.757
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0.744,
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0.78,
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0.79
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0.692,
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0.744,
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0.78,
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0.788,
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0.79
|
|
]
|
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},
|
|
"targets": [
|
|
"dp"
|
|
]
|
|
},
|
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"AGA|combo": {
|
|
"label": "남성형 탈모 · 피나+미녹 병용",
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|
"drug": "combo",
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|
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0.25,
|
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0.5,
|
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1,
|
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1.5,
|
|
2,
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|
3,
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|
4,
|
|
6,
|
|
9,
|
|
12,
|
|
18,
|
|
24,
|
|
36
|
|
],
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0.85,
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0.85,
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0.85,
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0.85,
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0.792,
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0.694,
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0.616,
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0.502,
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0.404,
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|
0.353,
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|
0.314,
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0.404,
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0.414,
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|
0.412
|
|
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0.412
|
|
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|
|
0.399,
|
|
0.449,
|
|
0.521,
|
|
0.584,
|
|
0.616,
|
|
0.641,
|
|
0.648,
|
|
0.65
|
|
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|
|
0.3,
|
|
0.3,
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|
0.3,
|
|
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|
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|
|
0.399,
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|
0.449,
|
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|
|
0.584,
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0.616,
|
|
0.641,
|
|
0.648,
|
|
0.65
|
|
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|
|
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|
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|
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|
0.403,
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|
0.563,
|
|
0.666,
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|
0.756,
|
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|
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|
|
0.847,
|
|
0.85
|
|
],
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|
0.666,
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0.756,
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0.802,
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0.847,
|
|
0.85
|
|
],
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|
0.85
|
|
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|
|
0.69,
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|
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|
|
0.755,
|
|
0.757
|
|
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|
0.438,
|
|
0.501,
|
|
0.552,
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|
0.626,
|
|
0.69,
|
|
0.722,
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|
0.748,
|
|
0.755,
|
|
0.757
|
|
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|
|
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|
|
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|
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|
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|
0.755,
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|
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|
|
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|
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|
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|
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0.15,
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|
0.226,
|
|
0.354,
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0.457,
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|
0.605,
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|
|
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|
0.865,
|
|
0.87
|
|
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|
0.354,
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0.457,
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0.605,
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0.734,
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0.8,
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|
0.852,
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0.865,
|
|
0.87
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|
]
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|
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|
|
"androgen",
|
|
"dp",
|
|
"hair",
|
|
"wnt",
|
|
"wnt_antag"
|
|
]
|
|
},
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|
|
"label": "원형 탈모 · 무치료",
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|
|
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|
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|
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|
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|
|
1.5,
|
|
2,
|
|
3,
|
|
4,
|
|
6,
|
|
9,
|
|
12,
|
|
18,
|
|
24,
|
|
36
|
|
],
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0.85,
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|
0.85,
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|
0.85,
|
|
0.85
|
|
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|
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|
|
0.85
|
|
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0.9,
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0.9,
|
|
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|
|
],
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0.9,
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0.9,
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0.9,
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0.9,
|
|
0.9
|
|
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|
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0.9,
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0.9,
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0.9,
|
|
0.9
|
|
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0.9,
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|
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|
|
0.9
|
|
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|
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|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
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|
|
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0.9,
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0.9,
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0.9,
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|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
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|
|
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|
|
0.78,
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|
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|
|
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|
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|
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|
0.78,
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|
0.78,
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|
0.78,
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|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
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|
|
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|
0.78,
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0.78,
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0.78,
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0.78,
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|
0.78,
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|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
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|
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|
|
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|
|
0.22,
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|
0.22,
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|
0.22,
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|
0.22,
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0.22,
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0.22,
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0.22,
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|
0.22,
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|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
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|
|
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0.22,
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0.22,
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0.22,
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0.22,
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|
0.22,
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0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
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|
|
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|
|
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|
0.22,
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|
0.22,
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|
0.22,
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0.22,
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0.22,
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0.22,
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|
0.22,
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|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
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|
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0.22,
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|
0.22,
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|
0.22,
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|
0.22,
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|
0.22,
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|
0.22,
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|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22
|
|
],
|
|
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|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
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|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
],
|
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|
|
0.3,
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|
0.3,
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|
0.3,
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|
0.3,
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|
0.3,
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0.3,
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|
0.3,
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0.3,
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|
0.3,
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|
0.3,
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|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
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|
|
0.35,
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|
0.35,
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|
0.35,
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|
0.35,
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|
0.35,
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|
0.35,
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|
0.35,
|
|
0.35,
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|
0.35,
|
|
0.35,
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|
0.35,
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|
0.35,
|
|
0.35,
|
|
0.35
|
|
],
|
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|
|
0.35,
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|
0.35,
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0.35,
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|
0.35,
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0.35,
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0.35,
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0.35,
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|
0.35,
|
|
0.35
|
|
],
|
|
"ALPL": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35
|
|
],
|
|
"KRT15": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4
|
|
],
|
|
"CD34": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4
|
|
],
|
|
"LGR5": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4
|
|
],
|
|
"KRT85": [
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15
|
|
],
|
|
"KRT35": [
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15
|
|
]
|
|
},
|
|
"targets": []
|
|
},
|
|
"AA|JAK_inhibitor": {
|
|
"label": "원형 탈모 · JAK 억제제",
|
|
"drug": "JAK_inhibitor",
|
|
"months": [
|
|
0,
|
|
0.25,
|
|
0.5,
|
|
1,
|
|
1.5,
|
|
2,
|
|
3,
|
|
4,
|
|
6,
|
|
9,
|
|
12,
|
|
18,
|
|
24,
|
|
36
|
|
],
|
|
"activity": {
|
|
"AR": [
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85
|
|
],
|
|
"SRD5A2": [
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85,
|
|
0.85
|
|
],
|
|
"IFNG": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.812,
|
|
0.734,
|
|
0.605,
|
|
0.504,
|
|
0.365,
|
|
0.252,
|
|
0.198,
|
|
0.161,
|
|
0.152,
|
|
0.15
|
|
],
|
|
"CD8A": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.812,
|
|
0.734,
|
|
0.605,
|
|
0.504,
|
|
0.365,
|
|
0.252,
|
|
0.198,
|
|
0.161,
|
|
0.152,
|
|
0.15
|
|
],
|
|
"HLA-DQB1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.812,
|
|
0.734,
|
|
0.605,
|
|
0.504,
|
|
0.365,
|
|
0.252,
|
|
0.198,
|
|
0.161,
|
|
0.152,
|
|
0.15
|
|
],
|
|
"CXCL10": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.812,
|
|
0.734,
|
|
0.605,
|
|
0.504,
|
|
0.365,
|
|
0.252,
|
|
0.198,
|
|
0.161,
|
|
0.152,
|
|
0.15
|
|
],
|
|
"DKK1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"SFRP1": [
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9,
|
|
0.9
|
|
],
|
|
"BMP4": [
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
|
|
"ID1": [
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78,
|
|
0.78
|
|
],
|
|
"WNT10B": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.244,
|
|
0.265,
|
|
0.3,
|
|
0.328,
|
|
0.366,
|
|
0.396,
|
|
0.411,
|
|
0.421,
|
|
0.423,
|
|
0.424
|
|
],
|
|
"CTNNB1": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.244,
|
|
0.265,
|
|
0.3,
|
|
0.328,
|
|
0.366,
|
|
0.396,
|
|
0.411,
|
|
0.421,
|
|
0.423,
|
|
0.424
|
|
],
|
|
"LEF1": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.244,
|
|
0.265,
|
|
0.3,
|
|
0.328,
|
|
0.366,
|
|
0.396,
|
|
0.411,
|
|
0.421,
|
|
0.423,
|
|
0.424
|
|
],
|
|
"AXIN2": [
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.22,
|
|
0.244,
|
|
0.265,
|
|
0.3,
|
|
0.328,
|
|
0.366,
|
|
0.396,
|
|
0.411,
|
|
0.421,
|
|
0.423,
|
|
0.424
|
|
],
|
|
"SHH": [
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
],
|
|
"GLI1": [
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3,
|
|
0.3
|
|
],
|
|
"SOX2": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.374,
|
|
0.394,
|
|
0.429,
|
|
0.456,
|
|
0.493,
|
|
0.523,
|
|
0.537,
|
|
0.547,
|
|
0.549,
|
|
0.55
|
|
],
|
|
"VCAN": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.374,
|
|
0.394,
|
|
0.429,
|
|
0.456,
|
|
0.493,
|
|
0.523,
|
|
0.537,
|
|
0.547,
|
|
0.549,
|
|
0.55
|
|
],
|
|
"ALPL": [
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.35,
|
|
0.374,
|
|
0.394,
|
|
0.429,
|
|
0.456,
|
|
0.493,
|
|
0.523,
|
|
0.537,
|
|
0.547,
|
|
0.549,
|
|
0.55
|
|
],
|
|
"KRT15": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.435,
|
|
0.465,
|
|
0.516,
|
|
0.555,
|
|
0.61,
|
|
0.654,
|
|
0.675,
|
|
0.69,
|
|
0.693,
|
|
0.694
|
|
],
|
|
"CD34": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.435,
|
|
0.465,
|
|
0.516,
|
|
0.555,
|
|
0.61,
|
|
0.654,
|
|
0.675,
|
|
0.69,
|
|
0.693,
|
|
0.694
|
|
],
|
|
"LGR5": [
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.4,
|
|
0.435,
|
|
0.465,
|
|
0.516,
|
|
0.555,
|
|
0.61,
|
|
0.654,
|
|
0.675,
|
|
0.69,
|
|
0.693,
|
|
0.694
|
|
],
|
|
"KRT85": [
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.235,
|
|
0.309,
|
|
0.433,
|
|
0.53,
|
|
0.664,
|
|
0.773,
|
|
0.824,
|
|
0.86,
|
|
0.868,
|
|
0.87
|
|
],
|
|
"KRT35": [
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.15,
|
|
0.235,
|
|
0.309,
|
|
0.433,
|
|
0.53,
|
|
0.664,
|
|
0.773,
|
|
0.824,
|
|
0.86,
|
|
0.868,
|
|
0.87
|
|
]
|
|
},
|
|
"targets": [
|
|
"hair",
|
|
"immune"
|
|
]
|
|
}
|
|
},
|
|
"groups": {
|
|
"androgen": "안드로겐 드라이버",
|
|
"wnt_antag": "Wnt 길항",
|
|
"wnt": "Wnt(친모발)",
|
|
"bmp": "BMP(항모발)",
|
|
"shh": "SHH",
|
|
"dp": "진피유두",
|
|
"hfsc": "모낭줄기세포",
|
|
"hair": "모발 산출",
|
|
"immune": "면역(AA)"
|
|
}
|
|
} |